3-Ethylthiophen-2-amine | 124701-11-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 3-Ethylthiophen-2-amine
• CAS: 124701-11-7
• 化学式: C₆H₉NS
• 分子量: 127.21
• InChiKey: OAOSOXNBIUHVLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis
  申请人：Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

  公开号：EP2266984A1

  公开（公告）日：2010-12-29

  Compounds according to the general formula (I) their solvates, hydrates, esters and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.

  化合物按照一般公式（I）及其溶剂化物、水合物、酯和药学上可接受的盐，用于调节Wnt信号通路活性以及用作药物，优选用于治疗癌症。
• Tricyclic Pyrimidine Derivatives as Wnt antagonists
  申请人：Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

  公开号：EP2266985A1

  公开（公告）日：2010-12-29

  The present invention relates to compounds having the general formula (I) with the definitions of X1 - X3, Y1, Y2, L1, R1 and R2 given below and/or solvates, hydrates, esters and pharmaceutically acceptable salts thereof. Furthermore, the invention relates to the use of said compounds for modulating of the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.

  本发明涉及具有通式（I）的化合物，其中X1 - X3，Y1，Y2，L1，R1和R2的定义如下，以及/或其溶剂，水合物，酯和药学上可接受的盐。此外，本发明涉及使用上述化合物来调节Wnt信号通路活性以及它们作为药物的用途，优选用于治疗癌症。
• TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS
  申请人：Fuchs Florian

  公开号：US20120157481A1

  公开（公告）日：2012-06-21

  The present invention relates to compounds having the general formula (I) with the definitions of X1-X3, Y1, Y2, L1, R1 and R2 given below and/or solvates, hydrates, esters and pharmaceutically acceptable salts thereof. Furthermore, the invention relates to the use of said compounds for modulating of the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.

  本发明涉及具有以下X1-X3，Y1，Y2，L1，R1和R2定义和/或其溶剂，水合物，酯和药物可接受的盐的通式（I）的化合物。此外，本发明涉及使用上述化合物调节Wnt信号通路活性以及它们作为药物的用途，优选用于治疗癌症。
• Anticonvulsive compositions
  申请人：NEW YORK UNIVERSITY

  公开号：EP0042626A2

  公开（公告）日：1981-12-30

  An orally administered pharmaceutical formulation comprising a solid dosage form containing an aliphatic amino acid compound in which the carboxylic acid and primary amine are separated by three or four units. Administered in an acid pH range, the formulation is useful in the treatment of convulsive disorders and also has anxiolytic and sedative properties.

  一种口服药物制剂，由固体剂型组成，含有一种脂肪族氨基酸化合物，其中的羧酸和伯胺由三个或四个单位分开。该制剂在酸性 pH 值范围内给药，可用于治疗惊厥性疾病，还具有抗焦虑和镇静作用。
• WATER-SOLUBLE TRIAZOLE FUNGICIDE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP1362856B1

  公开（公告）日：2008-09-10