4-amino-4-methoxymethylpiperidine | 412357-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-amino-4-methoxymethylpiperidine
• 英文别名: 4-(Methoxymethyl)piperidin-4-amine
• CAS: 412357-29-0
• 化学式: C₇H₁₆N₂O
• mdl: MFCD19214144
• 分子量: 144.217
• InChiKey: UPSNDLFWKRCVCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  tert-butyl 4-amino-4-(methoxymethyl)piperidine-1-carboxylate 生成 4-amino-4-methoxymethylpiperidine
  参考文献：
  名称：

  NITROGENOUS FIVE-MEMBERED RING COMPOUNDS

  摘要：

  公开号：

  EP1323710B1

文献信息

• Process for the Preparation of Sufentanil Base and Related Compounds
  申请人：ORR Brian

  公开号：US20120071659A1

  公开（公告）日：2012-03-22

  The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously utilizes more cost effective and/or less hazardous reagents, including a dispersion comprising between about 50% and about 70% by weight (based on the total weight of the dispersion) of an alkali metal hydride, such as sodium hydride, as well as eliminates the need for expensive and/or time consuming purification techniques.

  本公开涉及一种改进的制备各种哌啶衍生物的方法。更具体地说，本公开涉及一种改进的制备舒芬太尼碱（1）和相关化合物的方法，该方法利用更具成本效益和/或更少危险的试剂，包括一种分散物，其包含约50%至约70%的重量（基于分散物总重量）的碱金属氢化物，如氢化钠，并且消除了昂贵和/或耗时的纯化技术的需求。
• Nitrogenous five-membered ring compounds
  申请人：Yasuda Kosuke

  公开号：US20050054678A1

  公开（公告）日：2005-03-10

  The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein symbols in the formula have the following meanings; A: —CH 2 — or —S—, B: CH or N, R 1 : H, a lower alkyl group, etc., X: a single bonding arm, —CO—, -Alk-CO—, —COCH 2 —, -Alk-O—, —O—CH 2 —, —SO 2 —, —S—, —COO—, —CON(R 3 )—, -Alk-CON(R 3 )—, —CON(R 3 )CH 2 —, —NHCH 2 —, etc., R 3 : hydrogen atom or a lower alkyl group, Alk: a lower alkylene group, and R 2 : (1) a cyclic group which may be substituted, (2) a substituted amino group, etc., provided that when X is —CO—, then B is N, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种脂肪族含氮5元环化合物，其化学式为[I]，其中式中符号的含义如下：A：—CH2—或—S—，B：CH或N，R1：H、低碳基等，X：单键臂，—CO—、-Alk-CO—、—COCH2—、-Alk-O—、—O—CH2—、—SO2—、—S—、—COO—、—CON(R3)—、-Alk-CON(R3)—、—CON(R3)CH2—、—NHCH2—等，R3：氢原子或低碳基，Alk：低碳亚基，R2：(1)可能被取代的环状基团，(2)取代的氨基团等，但当X是—CO—时，B为N，或其药学上可接受的盐。
• Nitrogen-containing 5-membered ring compound
  申请人：Yasuda Kosuke

  公开号：US20060241146A1

  公开（公告）日：2006-10-26

  The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein symbols in the formula have the following meanings; A: —CH 2 — or —S—, B: CH or N, R 1 H, a lower alkyl group, etc., X: a single bonding arm, —CO—, —Alk—CO—, —COCH 2 —, —Alk—O—, —O—CH 2 —, —SO 2 —, —S—, —COO—, —CON(R 3 )—, —Alk—CON(R 3 )—, —CON(R 3 )CH 2 —, —NHCH 2 —, etc., R 3 : hydrogen atom or a lower alkyl group, Alk: a lower alkylene group,,and. R 2 : (1) a cyclic group which may be substituted, (2) a substituted amino group, etc., provided that when X is —CO—, then B is N, or a pharmaceutically acceptable salt thereof.

  本发明提供一种脂肪族含氮5元环化合物，其化学式表示为[I]，其中式中符号的含义如下：A：—CH2—或—S—，B：CH或N，R1：H、低碳烷基等，X：单键臂、—CO—、—Alk—CO—、—COCH2—、—Alk—O—、—O—CH2—、—SO2—、—S—、—COO—、—CON(R3)—、—Alk—CON(R3)—、—CON(R3)CH2—、—NHCH2—等，R3：氢原子或低碳烷基，Alk：低碳烷基，R2：（1）可取代的环状基团，（2）取代的氨基基团等，但当X为—CO—时，B为N，或其药学上可接受的盐。
• IMPROVED PROCESS FOR THE PREPARATION OF SUFENTANIL BASE AND RELATED COMPOUNDS
  申请人：Mallinckrodt LLC

  公开号：EP2616464A2

  公开（公告）日：2013-07-24
• US7138397B2
  申请人：——

  公开号：US7138397B2

  公开（公告）日：2006-11-21