tris(2-phenylethyl) phosphite | 59924-20-8

• 分子结构分类: 有机化合物 - 有机磷化合物 - 亚磷酸三烷基酯
• 英文名称: tris(2-phenylethyl) phosphite
• 英文别名: Tris-(β-phenaethyl)-phosphit；phosphorous acid triphenethyl ester；Phosphorigsaeure-triphenaethylester
• CAS: 59924-20-8
• 化学式: C₂₄H₂₇O₃P
• 分子量: 394.45
• InChiKey: LRQDDWFPGOHSBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  28
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tris(2-phenylethyl) phosphite 、 triethyloxonium fluoroborate 生成 Ethyl-tris-<2-phenyl-ethoxy>-phosphonium-fluoroborat
  参考文献：
  名称：

  Dimroth,K.; Nuerrenbach,A., Chemische Berichte, 1960, vol. 93, p. 1649 - 1658

  摘要：

  DOI：
• 作为产物：
  描述：

  苯乙醇 在 乙醚 、 N,N-二甲基苯胺 、 三氯化磷 作用下， 生成 tris(2-phenylethyl) phosphite
  参考文献：
  名称：

  Arbusow; Winogradowa, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1951, p. 733,738

  摘要：

  DOI：

文献信息

• 一种亲脂性荧光素探针及其制备方法
  申请人：天津全和诚科技有限责任公司

  公开号：CN112679543B

  公开（公告）日：2022-07-22

  本申请涉及亲脂性荧光素探针领域，具体公开了一种亲脂性荧光素探针及其制备方法。根据本申请的亲脂性荧光素探针由以下化学式1表示，其中，R为C1～C20的亚烷基或亚环烷基；R’为C1～C20的烷基、环烷基、芳烷基、芳环烷基、烷芳基或环烷芳基。所述亲脂性荧光素探针稳定性较高，不易自水解，而在脂酶的作用下能够快速水解释放出荧光素，因此对脂酶的具有非常高亲和作用力以及非常低的检出限。此外，根据本申请的制备方法操作简单，产率高。[化学式1]
• FOSAPREPITANT PHOSPHATE INTERMEDIATE AND PREPARATION METHOD THEREFOR
  申请人：Zhejiang Huahai Pharmaceutical Co., Ltd.

  公开号：US20190144477A1

  公开（公告）日：2019-05-16

  Provided are a fosaprepitant phosphate intermediate (IV) preparation method, a fosaprepitant phosphate intermediate (IV-A) and a method of (AA) for preparing fosaprepitant dimeglumine by using the intermediate (IV-A). IV: R 1 and R 2 are independently selected from C1-C7 alkyl groups or benzyl groups; IV-A: R 1 and R 2 are independently selected from C1-C7 alkyl groups, and R 1 and R 2 are not both benzyl groups.

  提供了一种fosaprepitant磷酸盐中间体（IV）的制备方法，一种fosaprepitant磷酸盐中间体（IV-A）和一种利用中间体（IV-A）制备fosaprepitant二甲胍的方法（AA）。IV：R1和R2分别选择C1-C7烷基或苄基；IV-A：R1和R2分别选择C1-C7烷基，且R1和R2不同时为苄基。
• Latent mercaptans as multi-functional additives for halogen-containing polymer compositions
  申请人：——

  公开号：US20030216493A1

  公开（公告）日：2003-11-20

  Halogen-containing polymer compositions comprising a latent mercaptan-containing heat stabilizer composition substantially free from the offensive odor typically associated with mercaptans are protected during processing by the degradation products of the latent (i.e., blocked) mercaptan which include a free mercaptan. Other products of the degradation are believed to include carbocations of the blocking moiety which are stabilized by a molecular structure in which the electron deficiency is shared by several groups. The latent mercaptan may be the sole heat stabilizer additive but the free mercaptan released during processing may also synergize the activity of metal-based heat stabilizers such as metal salts and organometallic stabilizers such as organotin carboxylates and mercaptides in the polymer composition. The odor of primary mercaptan-containing heat stabilizers in halogenated polymer compositions is masked by a small amount of a latent mercaptan. The latent mercaptans also serve as intermediates in the preparation of anti-oxidants, anti-microbial agents, photostabilizers, and primary heat stabilizers. Highly effective heat stabilizers are prepared by the condensation of formaldehyde and a para-phenol and further condensation of the crude product with a mercapto-containing compound.

  含卤素聚合物组合物包括一种潜在的巯基含量热稳定剂组合物，该组合物基本上不含有通常与巯基相关联的刺激性气味，在加工过程中通过潜在（即被阻断的）巯基的降解产物（包括自由巯基）来保护。降解的其他产物被认为包括阻断基的碳正离子，其通过电子亏损由几个基团共享的分子结构稳定。潜在巯基可以是唯一的热稳定剂添加剂，但在加工过程中释放的自由巯基也可以协同作用于金属基热稳定剂，如金属盐和有机金属稳定剂，如有机锡羧酸盐和巯基化合物在聚合物组合物中的活性。通过少量潜在巯基掩盖含有主要巯基热稳定剂的卤化聚合物组合物的气味。潜在巯基还可用作抗氧化剂、抗微生物剂、光稳定剂和主要热稳定剂的制备中间体。通过甲醛和对苯酚的缩合，并将粗产品与含巯基的化合物进一步缩合，可以制备高效的热稳定剂。
• LATENT MERCAPTANS AS MULTI-FUNCTIONAL ADDITIVES FOR HALOGEN-CONTAINING POLYMER COMPOSITIONS
  申请人：——

  公开号：US20020068780A1

  公开（公告）日：2002-06-06

  Halogen-containing polymer compositions comprising a latent mercaptan-containing heat stabilizer composition substantially free from the offensive odor typically associated with mercaptans are protected during processing by the degradation products of the latent (i.e., blocked) mercaptan which include a free mercaptan. Other products of the degradation are believed to include carbocations of the blocking moiety which are stabilized by a molecular structure in which the electron deficiency is shared by several groups. The latent mercaptan may be the sole heat stabilizer additive but the free mercaptan released during processing may also synergize the activity of metal-based heat stabilizers such as metal salts and organometallic stabilizers such as organotin carboxylates and mercaptides in the polymer composition. The odor of primary mercaptan-containing heat stabilizers in halogenated polymer compositions is masked by a small amount of a latent mercaptan. The latent mercaptans also serve as intermediates in the preparation of anti-oxidants, anti-microbial agents, photostabilizers, and primary heat stabilizers. Highly effective heat stabilizers are prepared by the condensation of formaldehyde and a para-phenol and further condensation of the crude product with a mercapto-containing compound.

  含卤素的聚合物组合物包括一种潜在的巯基含量热稳定剂组合物，该组合物基本上不含通常与巯基相关的刺激性气味，通过潜在（即阻塞）巯基的降解产物，包括自由巯基，来保护加工过程中的聚合物组合物。降解的其他产物被认为包括阻塞基的碳正离子，其由多个基团共享电子亏损的分子结构稳定。潜在巯基可以是唯一的热稳定剂添加剂，但在加工过程中释放的自由巯基也可以协同金属基热稳定剂（如金属盐）和有机金属稳定剂（如有机锡羧酸盐和巯基化合物）的活性。在卤化聚合物组合物中，主要巯基含量热稳定剂的气味被少量潜在巯基掩盖。潜在巯基还可用作抗氧化剂、抗微生物剂、光稳定剂和主要热稳定剂的制备中间体。通过甲醛和对苯酚的缩聚，并将粗品与含巯基化合物进一步缩聚，制备出高效的热稳定剂。
• Process for providing monovalent and polyvalent metal, particularly antimony, mercaptocarboxylic acid ester salts; monovalent and polyvalent metal mercaptocarboxylic acid salts; polyol mercaptocarboxylic acid monoesters, and esters of such polyol mercaptocarboxylic acid esters with a mercaptocarboxylic acid; stabilizer compositions for polyvinyl chloride resins comprising such compounds; and polyvinyl chloride resin compositions comprising a stabilizing amount of such compounds
  申请人：Mack, Gerry

  公开号：EP0024919A2

  公开（公告）日：1981-03-11

  Antimony mercaptocarboxylic acid esters are provided having the formula: wherein: R is selected from the group consisting of hydrogen, alkyl having from one to about eighteen carbon atoms and alkylene linked with R2 in a ring having from three to about eight carbon atoms; R2 is selected from the group consisting of alkyl having from one to about eighteen carbon atoms, phenyl, and alkylene linked with R, in a ring having from three to about eight carbon atoms; R3 is selected from the group consisting of hydrogen and alkyl having from one to three carbon atoms; R4 is selected from the group consisting of alkyl, aryl, alkylaryl, alkoxycarbonyl-alkylene and acyloxyalkylene having from three to about twenty carbon atoms, the alkylene having from two to about six carbon atoms; R5 is selected from the group consisting of alkylene and cycloalkylene having from one to about eighteen carbon atoms, and such groups having from one to four hydroxyl groups; Z is a bivalent alkylene group having from one to five carbon atoms and carrying the sulfur in a position alpha or beta to -OOC-; and n is a number from 1 to 3. A process for preparing such antimony compounds is also provided, as well as predecessor intermediates, and stabilizer compositions for polyvinyl chloride resin compositions comprising such antimony compounds, if desired with other polyvinyl chloride resin stabilizers.

  巯基羧酸锑酯的化学式如下 其中 R 选自氢、具有 1 至约 18 个碳原子的烷基和与 R2 连接成具有 3 至约 8 个碳原子的环的亚烷基组成的组； R2 选自具有 1 至约 18 个碳原子的烷基、苯基和与 R2 连接在具有 3 至约 8 个碳原子的环中的亚烷基组成的组； R3 选自由氢和具有一至三个碳原子的烷基组成的组； R4 选自具有 3 至约 20 个碳原子的烷基、芳基、烷芳基、烷氧羰基亚烷基和酰氧基亚烷基组成的组，其中亚烷基具有 2 至约 6 个碳原子； R5 选自具有 1 至约 18 个碳原子的亚烷基和环亚烷基，以及具有 1 至 4 个羟基的此类基团； Z 是二价亚烷基，具有 1 至 5 个碳原子，并在 -OOC- 的α或β位上带有硫；以及 n 是 1 至 3 的数字。 本发明还提供了制备此类锑化合物的工艺以及前身中间体，并提供了包含此类锑化合物的聚氯乙烯树脂组合物的稳定剂组合物（如需要与其他聚氯乙烯树脂稳定剂一起使用）。