6-Carbethoxy-6-azabicyclo<3.1.0>hexan | 50990-01-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 6-Carbethoxy-6-azabicyclo<3.1.0>hexan
• 英文别名: 6-Carboethoxy-6-azabicyclo<3.1.0>hexan；6-aza-bicyclo[3.1.0]hexane-6-carboxylic acid ethyl ester；Ethyl 6-azabicyclo[3.1.0]hexane-6-carboxylate
• CAS: 50990-01-7
• 化学式: C₈H₁₃NO₂
• 分子量: 155.197
• InChiKey: MURBGPSZVYAFQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  29.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Method of converting functional group through halogen-metal exchange reaction
  申请人：——

  公开号：US20030130511A1

  公开（公告）日：2003-07-10

  A method by which a halogen atom of a halogen compound can be efficiently replaced with an electrophilic group. Also provided are: a reagent for converting a functional group through a halogen-metal exchange reaction, characterized by comprising either a mixture of a magnesium compound represented by the formula R 1 —Mg—X (I) (wherein R 1 represents a halogen atom or an optionally substituted hydrocarbon residue; and X 1 represents a halogen atom) and an organolithium compound represented by the formula R 2 —Li (II) (wherein R 2 represents an optionally substituted hydrocarbon residue) or a product of the reaction of the magnesium compound with the organolithium compound; and a process for producing with the reagent a compound in which a halogen atom of a halogen compound has been replaced with an electrophilic group.

  一种通过卤素化合物的卤素原子有效地被电亲团取代的方法。还提供了：一种用于通过卤金属交换反应将功能团转化的试剂，其特征在于包括由表示为R1—Mg—X（I）的镁化合物的混合物（其中R1表示卤素原子或可选择地取代的碳氢残基；X1表示卤素原子）和由表示为R2—Li（II）的有机锂化合物（其中R2表示可选择地取代的碳氢残基）组成，或者是镁化合物与有机锂化合物反应的产物；以及使用该试剂制备一种化合物的过程，其中该化合物的卤素化合物的卤素原子已被电亲团取代。
• Method of substituent introduction through halogen-metal exchange reaction
  申请人：Kato Shinji

  公开号：US20050104233A1

  公开（公告）日：2005-05-19

  A method of exchanging a halogen atom of a halide, which has a group containing an acidic proton and in which one or more halogen atom(s) is/are substituted on a carbon atom of the carbon-carbon double bond, with a metal atom by halogen-metal-exchange reaction and introducing an electrophilic reagent into the carbon atom to which the metal atom is attached. The above method is an industrially excellent method of introducing a substituent by halogen-metal exchange reaction.

  一种通过卤金属交换反应交换含有酸性质子的基团并在碳－碳双键的碳原子上取代一个或多个卤素原子的卤化物中的卤素原子与金属原子，并向金属原子所连接的碳原子引入亲电试剂的方法。上述方法是一种通过卤金属交换反应引入取代基的工业优秀方法。
• Process for exchanging functional groups by halogen-metal exchange reaction
  申请人：Iida Takehiko

  公开号：US20050156336A1

  公开（公告）日：2005-07-21

  A method by which a halogen atom of a halogen compound can be efficiently replaced with an electrophilic group. Also provided are: a reagent for converting a functional group through a halogen-metal exchange reaction, characterized by comprising either a mixture of a magnesium compound represented by the formula R 1 —Mg—X (I) (wherein R 1 represents a halogen atom or an optionally substituted hydrocarbon residue; and X 1 represents a halogen atom) and an organolithium compound represented by the formula R 2 —Li (II)(wherein R 2 represents an optionally substituted hydrocarbon residue) or a product of the reaction of the magnesium compound with the organolithium compound; and a process for producing with the reagent a compound in which a halogen atom of a halogen compound has been replaced with an electrophilic group.

  一种通过电泳性基团高效替换卤素化合物中卤素原子的方法。此外，还提供了一种通过卤素-金属交换反应转化官能团的试剂，其特征在于包含式R1-Mg-X（I）（其中R1表示卤素原子或可选取代的碳氢残基；X1表示卤素原子）的镁化合物和式R2-Li（II）（其中R2表示可选取代的碳氢残基）的有机锂化合物的混合物，或者是镁化合物与有机锂化合物反应的产物；以及使用该试剂制备一种卤素化合物中卤素原子被电泳性基团替换的化合物的方法。
• METHOD OF CONVERTING FUNCTIONAL GROUP THROUGH HALOGEN-METAL EXCHANGE REACTION
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1253152B1

  公开（公告）日：2009-11-04
• EP1510510A1
  申请人：——

  公开号：EP1510510A1

  公开（公告）日：2005-03-02