tris(4-methylaminophenyl)methane | 215180-91-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: tris(4-methylaminophenyl)methane
• 英文别名: 4,4',4''-Methanetriyltris(N-methylaniline)；4-[bis[4-(methylamino)phenyl]methyl]-N-methylaniline
• CAS: 215180-91-9
• 化学式: C₂₂H₂₅N₃
• 分子量: 331.461
• InChiKey: AEMRGDCCHBQTGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  36.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  tris(4-formylaminophenyl)methane 以 四氢呋喃 、 水 为溶剂， 以70%的产率得到tris(4-methylaminophenyl)methane
  参考文献：
  名称：

  Compounds exhibiting thrombopoietin-like activities

  摘要：

  本发明的化合物是由以下一般式（1）表示的化合物：其中E代表从甲基亚基团和硝基亚基团组成的群体中选择的一种，R1代表从可选择的取代芳基和可选择的取代杂环烷基组成的群体中选择的一种，R2代表从氢原子和烷基组成的群体中选择的一种，W1代表氨基酸残基，A代表从羰基和磺酰基组成的群体中选择的一种，X1代表从可选择的取代烷基烯基团和可选择的取代烯基烷基团组成的群体中选择的一种，p代表0或1；以及它们的药理学上可接受的盐，具有类似于血小板生成素的活性。

  公开号：

  US20030162724A1

文献信息

• MELANIN PRODUCTION INHIBITOR
  申请人：Yokoyama Kouji

  公开号：US20110243865A1

  公开（公告）日：2011-10-06

  Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor comprises a compound represented by general formula (1) (excluding clotrimazole), and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent, wherein at least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group, wherein when one of R1 and R2 is an oxo group, the other is not present; and R3 is selected from a hydrogen atom, and a C 1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms, wherein the number of R3's present in the compound corresponds to the number of X's and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.

  披露了一种黑色素生产抑制剂，它对黑色素的生产具有出色的抑制活性且高度安全。该黑色素生产抑制剂包括由通用公式（1）表示的化合物（不包括克霉唑）和/或其药理上可接受的盐。在公式中，A1、A2和A3独立地选自氢原子、可能带有取代基的芳基团和可能带有取代基的芳香杂环团，其中至少A1、A2和A3之一选自芳基团和芳香杂环团，A1、A2和A3中包含的碳原子总数为6至50，并且当至少两个A1、A2和A3表示芳基团或芳香杂环团时，相邻的两个芳基或芳香杂环团可以通过烷基链或烯基链相互连接形成环；m代表0至2的整数；X代表异原子、氢原子或碳原子；R1和R2独立地选自氢原子和氧代基，其中当R1和R2之一是氧代基时，另一个不出现；R3选自氢原子和C 1-8 碳氢化合物组，其中一些或所有的氢原子或碳原子可能被异原子或异原子取代，其中化合物中存在的R3的数量对应于X的数量，并且当存在两个或更多R3时，R3独立地存在，并且相邻的两个R3可以相互连接以与X一起形成环，并且R3的末端可以与A1、A2和A3连接的碳原子结合，从而形成环。
• Fotochromes System, damit hergestellte Schichten und deren Verwendung
  申请人：BASF Aktiengesellschaft

  公开号：EP0239868A1

  公开（公告）日：1987-10-07

  Das fotochrome System, enthält einen oxidierbaren Leukofarbstoff und einen fotochemisch aktivierbaren Initiator, der den Leukofarbstoff in den Farbstoff überführt, wobei der Initiator ein Phenanthroimidazolderivat ist. Das fotochrome System eignet sich zur Herstellung fotochromer Schichten für Photoresists und Druckplatten.

  光致变色系统包含一种可氧化的白兰地染料和一种可光化学活化的引发剂，引发剂可将白兰地染料转化为染料，其中引发剂是一种菲咯咪唑衍生物。 这种光致变色系统适用于生产光刻胶和印版的光致变色层。
• COMPOUNDS EXHIBITING THROMBOPOIETIN-LIKE ACTIVITIES
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1291341A1

  公开（公告）日：2003-03-12

  The compounds of the invention are compounds represented by the following general formula (1): wherein E represents one selected from the group consisting of a methylidyne group and a nitrilo group, R1 represents one selected from the group consisting of optionally substituted aryl groups and optionally substituted heteroaryl groups, R2 represents one selected from the group consisting of a hydrogen atom and alkyl groups, W1 represents an amino acid residue, A represents one selected from the group consisting of a carbonyl group and a sulfonyl group, X1 represents one selected from the group consisting of optionally substituted alkylene groups and optionally substituted alkenylene groups, and p represents 0 or 1; and their pharmacologically acceptable salts, which exhibit thrombopoietin-like activity.

  本发明的化合物是由以下通式（1）表示的化合物： 其中 E 代表选自由甲炔基和亚硝基组成的组，R1 代表选自由取代芳基和选自由取代杂芳基组成的组，R2 代表选自由氢原子和烷基组成的组，W1 代表氨基酸残基，A 代表选自由羰基和磺酰基组成的组，X1 代表选自由取代亚烷基和选自由取代烯基组成的组，p 代表 0 或 1；及其药理上可接受的盐类，这些盐类具有类似血小板生成素的活性。
• Melanin production inhibitor
  申请人：Pola Chemical Industries Inc.

  公开号：EP2845587A2

  公开（公告）日：2015-03-11

  Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor comprises a compound represented by general formula (1) (excluding clotrimazole) and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent, wherein at least one of A1, A2 andA3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group, wherein when one of R1 and R2 is an oxo group, the other is not present; and R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms, wherein the number of R3's present in the compound corresponds to X and, when two or more R3' s are present, the R3' s are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.

  本发明公开了一种黑色素生成抑制剂，它对黑色素的生成具有极佳的抑制活性，且安全性高。黑色素生成抑制剂包括通式（1）代表的化合物（不包括克霉唑）和/或其药理上可接受的盐。式中，A1、A2 和 A3 独立选自氢原子、可具有取代基的芳基和可具有取代基的芳香杂环基团，其中 A1、A2 和 A3 中至少有一个选自芳基和芳香杂环基团、A1、A2 和 A3 所含的碳原子总数为 6 至 50，当 A1、A2 和 A3 中至少有两个代表芳基或芳香杂环基团时，相邻的两个芳基或芳香杂环基团可通过烷基链或烯基链相互结合形成一个环；m 代表 0 至 2 的整数； X 代表杂原子、氢原子或碳原子；R1 和 R2 分别独立地选自氢原子和氧代基团，其中当 R1 和 R2 中的一个是氧代基团时，另一个不存在；R3选自氢原子和C1-8烃基，其中一个或部分氢原子或碳原子可被一个或多个杂原子取代，其中化合物中存在的R3的数目与X相对应，当存在两个或多个R3's时，R3's独立存在，相邻的两个R3's可相互结合，与X一起形成一个环，R3的末端可与A1、A2和A3所结合的碳原子结合，从而形成一个环。
• MULTIFUNCTIONAL POROUS ARAMIDS (AEROGELS) AND FABRICATION THEREOF
  申请人：The Curators of the University of Missouri

  公开号：US20150111976A1

  公开（公告）日：2015-04-23

  The present disclosure provides a series of new and improved porous polyamide aerogels derived from multifunctional aromatics that combine the high mechanical strength of aramids with the pore structure of aerogels. The polyamide aerogels have a hyperbranched structure, relatively low density, high porosity and may be derived from functionalized monomers having more aromatic groups than functional groups. The present disclosure also provides a new method for producing the porous polyamide aerogels by polymerizing an aromatic multifunctional carboxylic acid or a ferrocene multifunctional carboxylic acid with a polyfunctional aromatic isocyanate at moderate reaction conditions followed by drying with liquid CO 2 . Also disclosed are various methods of use of these polyamide aerogels in a variety of applications.