n-Butyl nipecotic acid | 926275-70-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: n-Butyl nipecotic acid
• 英文别名: 1-butylpiperidine-3-carboxylic acid
• CAS: 926275-70-9
• 化学式: C₁₀H₁₉NO₂
• mdl: MFCD12169847
• 分子量: 185.26
• InChiKey: NRNDLXBGJIHXDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS
  申请人：Lin Xichen

  公开号：US20130012491A1

  公开（公告）日：2013-01-10

  Disclosed are pyrimidine derivatives for use as a sphingosine 1-phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis.

  本文披露了用作神经酰胺1-磷酸1（S1P1）受体激动剂的嘧啶衍生物，其制备方法，含有它们的药物组合物以及它们在治疗由S1P1受体介导的疾病或症状，尤其是多发性硬化症方面的用途。
• Ester substituted ion channel blockers and methods for use
  申请人：Nocion Therapeutics, Inc.

  公开号：US10927096B2

  公开（公告）日：2021-02-23

  The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

  本发明提供了式（I）化合物或其药学上可接受的盐类： 本发明的化合物、组合物、方法和试剂盒可用于治疗疼痛、瘙痒和神经源性炎症。
• ESTER SUBSTITUTED ION CHANNEL BLOCKERS AND METHODS FOR USE
  申请人：Noclon Therapeutics, Inc.

  公开号：US20200290991A1

  公开（公告）日：2020-09-17

  The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.
• [EN] SULFOXIMINES AS KINASE INHIBITORS<br/>[FR] SULFOXIMINES EN TANT QU'INHIBITEURS DE LA KINASE
  申请人：ALLERGAN INC

  公开号：WO2008061236A2

  公开（公告）日：2008-05-22

  [EN] The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
  [FR] La présente invention concerne des molécules organiques capables de moduler la transduction de signal de la tyrosine kinase afin de réguler, de moduler et/ou inhiber une prolifération cellulaire anormale.