1-Methylpiperidin-2-amine | 755716-66-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-Methylpiperidin-2-amine
• CAS: 755716-66-6
• 化学式: C₆H₁₄N₂
• 分子量: 114.19
• InChiKey: KJWNKJWHMQSPNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER<br/>[FR] DÉRIVÉS DE PYRROLO[2,3-D]PYRIMIDINE ET LEUR UTILISATION DANS LE TRAITEMENT DU CANCER
  申请人：SENTINEL ONCOLOGY LTD

  公开号：WO2021074251A1

  公开（公告）日：2021-04-22

  The invention provides compounds of the formula (1): or a salt or tautomer thereof wherein A, R1, R2, R3, R4, R5 and R6 are as defined herein. The compounds are inhibitors of Wee1 and/or PLK1 kinase and are envisaged to be useful in the treatment of cancers.

  这项发明提供了式（1）的化合物：或其盐或互变异构体，其中A、R1、R2、R3、R4、R5和R6如本文所定义。这些化合物是Wee1和/或PLK1激酶的抑制剂，预计在癌症治疗中有用。
• 4-Formyl amino-n-methylpiperidine derivatives, the use thereof as stabilisers and organic material stabilised therewith
  申请人：——

  公开号：US20030083406A1

  公开（公告）日：2003-05-01

  The present invention relates to 4-formylamino-N-methylpiperidine derivatives of the formula (I) 1 where the variables are as defined in the Description, to a process for preparing these piperidine derivatives, to the use of these piperidine derivatives of the invention, or prepared according to the invention, for stabilizing organic material, in particular for stabilizing plastics or coating materials, and also to the use of these piperidine derivatives of the invention, or prepared according to the invention, as light stabilizers or stabilizers for wood surfaces. The present invention further relates to stabilized organic material which comprises these piperidine derivatives of the invention or prepared according to the invention.

  本发明涉及通式(I)的4-甲酰氨基-N-甲基哌啶衍生物 1 其中变量如说明书中所定义，涉及制备这些哌啶衍生物的方法，涉及这些本发明的哌啶衍生物或按照本发明制备的哌啶衍生物用于稳定有机材料，特别是用于稳定塑料或涂料材料，还涉及这些本发明的哌啶衍生物或按照本发明制备的哌啶衍生物作为光稳定剂或木材表面的稳定剂的使用。 本发明还涉及包含这些本发明的哌啶衍生物或按照本发明制备的哌啶衍生物的稳定有机材料。
• [EN] HIV INHIBITORS<br/>[FR] INHIBITEURS DU VIH
  申请人：NEW YORK BLOOD CT INC

  公开号：WO2013036676A1

  公开（公告）日：2013-03-14

  Chemical compounds that inhibit retroviruses are presented herein. More particularly, this disclosure provides small molecule compounds that inhibit infection with, or treat infection caused by, human immunodeficiency viruses.

  本文介绍了抑制逆转录病毒的化合物。更具体地，本公开提供了抑制感染人类免疫缺陷病毒或治疗由其引起的感染的小分子化合物。
• [EN] SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES<br/>[FR] DERIVES DE 1,2,3,4-TÉTRAHYDROISOQUINOLÉINE SUBSTITUÉS
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2005118548A1

  公开（公告）日：2005-12-15

  The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) wherein R1, R2, R3 and X are as defined in the claims, and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to a mammal.

  这项发明涉及到新颖的1,2,3,4-四氢异喹啉衍生物，其化学式为(I)，其中R1、R2、R3和X如权利要求中所定义，并且它们作为活性成分用于制备药物组合物。该发明还涉及相关方面，包括制备这些化合物的方法、含有其中一个或多个化合物的药物组合物以及包括将这些化合物用于哺乳动物的治疗方法。
• [EN] QUINOXALINONE-3- ONE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS<br/>[FR] DERIVES DE QUINOXALINONE-3- ONE UTILISES COMME ANTAGONISTES DU RECEPTEUR D'OREXINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2004096780A1

  公开（公告）日：2004-11-11

  The invention relates to quinoxalinone derivatives of general Formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.General Formula (I) wherein X and R1-R9 are as defined in the description

  本发明涉及一般式(I)的喹喔啉酮衍生物及其在制备药物组合物中作为活性成分的用途。本发明还涉及相关方面，包括制备该化合物的过程，含有一个或多个该化合物的药物组合物，特别是它们作为促进睡眠的药物受体拮抗剂的用途。其中X和R1-R9如描述中所定义。