1'-(1H-indol-7-ylcarbonyl)-3H-spiro[2-benzofuran-1,4'-piperidine] | 1034352-75-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1'-(1H-indol-7-ylcarbonyl)-3H-spiro[2-benzofuran-1,4'-piperidine]
• 英文别名: 1H-Indol-7-ylspiro[isobenzofuran-1(3H),4a(2)-piperidin]-1a(2)-ylmethanone；1H-indol-7-yl(spiro[1H-2-benzofuran-3,4'-piperidine]-1'-yl)methanone
• CAS: 1034352-75-4
• 化学式: C₂₁H₂₀N₂O₂
• 分子量: 332.402
• InChiKey: JHOYDPHCJOLNML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  45.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• SPIROPIPERIDINE DERIVATIVES
  申请人：Bissantz Caterina

  公开号：US20080153861A1

  公开（公告）日：2008-06-26

  The present invention is concerned with novel spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of anxiety and depressive disorders and other diseases. The compounds of present invention are described with formula (I) wherein R 1 to R 5 , R 5 ′, R 7 to R 9 , R 7 ′, R 8 ′, X and Y are as defined in the specification.

  本发明涉及作为V1a受体拮抗剂的新颖螺环哌啶衍生物，其制备方法，含有它们的药物组合物以及它们用于治疗焦虑和抑郁症等疾病的用途。本发明的化合物用式(I)描述如下： 其中R1至R5，R5'，R7至R9，R7'，R8'，X和Y如规范中定义。
• Spiro-piperidine derivatives
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2535329A2

  公开（公告）日：2012-12-19

  The present invention is concerned with novel spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. The compounds of present invention are described with the general formula (I) wherein R1 to R5, R5', R7 to R9, R7', R8', X and Y are as defined in the specification.

  本发明涉及作为 V1a 受体拮抗剂的新型螺哌啶衍生物、它们的制造、含有它们的药物组合物以及它们作为药物的用途。本发明的活性化合物可用于预防和/或治疗焦虑症、抑郁症和其他疾病。本发明化合物的通式为 (I) 其中 R1 至 R5、R5'、R7 至 R9、R7'、R8'、X 和 Y 如说明书中所定义。
• SPIRO-PIPERIDINE DERIVATIVES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2097376A2

  公开（公告）日：2009-09-09
• US8084609B2
  申请人：——

  公开号：US8084609B2

  公开（公告）日：2011-12-27
• [EN] SPIRO-PIPERIDINE DERIVATIVES<br/>[FR] DÉRIVÉS DE SPIROPIPÉRIDINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2008077810A2

  公开（公告）日：2008-07-03

  [EN] The present invention is concerned with novel spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. The compounds of present invention are described with the general formula (I), wherein R¹ to R⁵, R^5', R⁷ to R⁹, R^7', R^8', X and Y are as defined in the specification.
  [FR] La présente invention concerne de nouveaux dérivés de spiropipéridine constituant des antagonistes du récepteur V1a, ainsi que leur fabrication, des compositions pharmaceutiques les contenant et leur utilisation comme médicaments. Les composés actifs selon l'invention sont utiles pour prévenir et/ou traiter l'anxiété et les troubles dépressifs et d'autres maladies. Lesdits composés sont représentés par la formule générale (I), dans laquelle R¹ à R⁵, R^5', R⁷ à R⁹, R^7', R^8', X et Y sont tels que définis dans la description.