4-(propinonylamino)-2,2,6,6-tetramethylpiperidine-1-oxyl | 21270-94-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(propinonylamino)-2,2,6,6-tetramethylpiperidine-1-oxyl
• 英文别名: N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)propanamide
• CAS: 21270-94-0
• 化学式: C₁₂H₂₄N₂O₂
• 分子量: 228.335
• InChiKey: VULMOPWNFFBLSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] NITROXIDE CONTAINING AMYLOID BINDING AGENTS FOR IMAGING AND THERAPEUTIC USES<br/>[FR] AGENTS DE LIAISON À L'AMYLOÏDE CONTENANT DU NITROXYDE UTILISÉS EN IMAGERIE ET À DES FINS THÉRAPEUTIQUES
  申请人：UNIV CALIFORNIA

  公开号：WO2017031239A1

  公开（公告）日：2017-02-23

  The present invention provides methods of using nitroxide spin-labeled amyloid beta-binding compounds to image amyloid. The present invention also provides nitroxide spin-labeled amyloid beta-binding compounds

  本发明提供了使用亚硝基自旋标记的淀粉样β结合化合物来成像淀粉样物质的方法。本发明还提供了亚硝基自旋标记的淀粉样β结合化合物。
• [EN] THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS THÉRAPEUTIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV MINNESOTA

  公开号：WO2021178690A1

  公开（公告）日：2021-09-10

  The invention provides a compound of formula (I): or a salt thereof, wherein A, B, R1, R2, R3 and X have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as therapeutic agents for treating diastolic dysfunction.

  该发明提供了一个式(I)的化合物或其盐，其中A、B、R1、R2、R3和X具有规范中描述的任何值，以及包含式I的化合物的组合物。这些化合物可用作治疗舒张功能障碍的治疗剂。
• Method For Producing Alpha, Beta-Unsaturated Carboxylic Acid
  申请人：Kawato Seiichi

  公开号：US20080064899A1

  公开（公告）日：2008-03-13

  The present invention provides a method for producing an α,β-unsaturated carboxylic acid in high yield. In particular, the present invention resides in a method for producing an α,β-unsaturated carboxylic acid by oxidation of an olefin or an α,β-unsaturated aldehyde with molecular oxygen in liquid phase in the presence of a catalyst containing at least palladium, wherein at least one compound selected from the group consisting of p-methoxyphenol, 4,4′-dihydroxytetraphenylmethane, 1,1,1-tris(p-hydroxyphenyl)ethane, compounds having an N-oxyl group in the molecule and compounds having an N-nitrosyl group in the molecule is caused to be coexistent.

  本发明提供了一种高产率生产α，β-不饱和羧酸的方法。具体来说，本发明涉及一种通过在液相中存在至少一种含有钯的催化剂的情况下，通过氧化烯烃或α，β-不饱和醛制备α，β-不饱和羧酸的方法，其中使得来自包括对甲氧基苯酚，4,4'-二羟基四苯甲烷，1,1,1-三(p-羟基苯基)乙烷，分子中含有N-氧基基团的化合物和分子中含有N-亚硝基基团的化合物的群组中的至少一种化合物共存。
• Decreasing method of N-oxyl compound
  申请人：Mitsubishi Rayon co., Ltd.

  公开号：US20030078425A1

  公开（公告）日：2003-04-24

  There is provided a superior decreasing method of an N-oxyl compound contained in an easily polymerizable material, according to which the N-oxyl compound contained in an easily polymerizable material can be sufficiently decreased and loss of the easily polymerizable material is little. The easily polymerizable material containing an N-oxyl compound and an acid are contacted with each other. In addition, not only the N-oxyl compound but also an organic titanium group compound contained in the easily polymerizable material can be sufficiently decreased.

  提供了一种优越的减少N-氧化物化合物的方法，该方法适用于易聚合材料中含有的N-氧化物化合物，根据该方法，易聚合材料中含有的N-氧化物化合物可以充分减少，易聚合材料的损失很小。将含有N-氧化物化合物和酸的易聚合材料相互接触。此外，不仅可以充分减少易聚合材料中的N-氧化物化合物，还可以充分减少易聚合材料中的有机钛化合物。
• Composition for the immediate stopping of a free-radical polymerization
  申请人：BASF SE

  公开号：US10221255B2

  公开（公告）日：2019-03-05

  A composition for the immediate stopping of a free-radical polymerization comprises a) an inhibitor for the free-radical polymerization selected from among phenothiazines, b) an aprotic solvent and c) an ionic liquid. It serves to stabilize free-radically polymerizable monomers against free-radical polymerization. For the immediate stopping of free-radical polymerizations, the composition is added to a free-radically polymerizing system.

  一种可立即阻止自由基聚合的组合物包括 a) 一种吩噻嗪类自由基聚合抑制剂；b) 一种烷基溶剂；c) 一种离子液体。其作用是稳定可自由基聚合的单体，防止自由基聚合。为了立即停止自由基聚合，可将该组合物加入自由基聚合体系中。