2-cyclopropyl-[1,2,4]triazolo[1,5,a]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并吡啶类
• 英文名称: 2-cyclopropyl-[1,2,4]triazolo[1,5,a]pyridine
• 英文别名: 2-Cyclopropyl-[1,2,4]triazolo[1,5-a]pyridine
• 化学式: C₉H₉N₃
• 分子量: 159.191
• InChiKey: AHGPOJIDRFUKKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(pyridin-2-yl)cyclopropylmethanamidine 在 四丁基溴化铵 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以89%的产率得到2-cyclopropyl-[1,2,4]triazolo[1,5,a]pyridine
  参考文献：
  名称：

  分子内电化学脱氢N–N键的形成，用于合成1,2,4-三唑并[1,5- a ]吡啶

  摘要：

  在温和且可扩展的电解条件下，已开发出无金属和无氧化剂的分子内脱氢N–N键的形成。从容易获得的N-（2-吡啶基）am有效地合成了各种有价值的1,2,4-三唑并[1,5- a ]吡啶。反应在恒定电流条件下，在简单的不分隔电池中进行，其中n Bu 4 NBr作为氧化还原介体和电解质。该方案适用于抗糖尿病化合物关键中间体的有效合成。

  DOI：

  10.1039/c9gc01895f

文献信息

• [EN] HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS<br/>[FR] ANTAGONISTES DES CANAUX CALCIQUES DE TYPE T À BASE D'AMIDE HÉTÉROCYCLIQUE
  申请人：MERCK & CO INC

  公开号：WO2009054983A1

  公开（公告）日：2009-04-30

  The present invention is directed to heterocycle amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及杂环酰胺化合物，它们是T型钙通道的拮抗剂，可用于治疗或预防涉及T型钙通道的疾病和疾病。该发明还涉及包含这些化合物的药物组合物以及在预防或治疗涉及T型钙通道的疾病中使用这些化合物和组合物。
• PhI(OAc)2-Mediated Regioselective Synthesis of 5-Guanidino-1,2,4-thiadiazoles and 1,2,4-Triazolo[1,5-a]pyridines via Oxidative N–S and N–N Bond Formation
  作者：Tumula Nagaraju、Palakodety Radha Krishna、Balasubramanian Sridhar、Nakka Mangarao

  DOI：10.1055/s-0037-1611854

  日期：2019.10

  construction of biologically important 5-guanidino-1,2,4-thiadiazole and 1,2,4-triazolo[1,5-a]pyridine derivatives has been developed. This new protocol involves the phenyliodine(III) diacetate [PhI(OAc)2]-mediated oxidative cyclization of thioureas/2-aminopyridines and imidates via N–S and N–N bond formation at ambient temperature. This method furnishes the versatile 5-guanidino-1,2,4-thiadiazoles and 1

  抽象的 已经开发了一种有效且快速的方法，用于构建生物学上重要的5-胍基-1,2,4-噻二唑和1,2,4-三唑并[1,5- a ]吡啶衍生物。该新方案涉及苯乙酸碘（III）双乙酸盐[PhI（OAc）2 ]介导的硫脲/ 2-氨基吡啶的氧化环化作用，并在环境温度下通过NS和NS键形成酰亚胺。该方法以可扩展的方式高效，优异的区域选择性提供了通用的5-胍基-1,2,4-噻二唑和1,2,4-三唑并[1,5- a ]吡啶。 已经开发了一种有效且快速的方法，用于构建生物学上重要的5-胍基-1,2,4-噻二唑和1,2,4-三唑并[1,5- a ]吡啶衍生物。该新方案涉及苯乙酸碘（III）双乙酸盐[PhI（OAc）2 ]介导的硫脲/ 2-氨基吡啶的氧化环化作用，并在环境温度下通过NS和NS键形成酰亚胺。该方法以可扩展的方式高效，优异的区域选择性提供了通用的5-胍基-1,2,4-噻二唑和1,2,4-三唑并[1,5-
• PYRAZINYL AMIDE-T TYPE CALCIUM CHANNEL ANTAGONISTS
  申请人：Barrow James C.

  公开号：US20100216816A1

  公开（公告）日：2010-08-26

  The present invention is directed to pyrazinyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及吡嗪基酰胺化合物，其是T型钙通道的拮抗剂，并且对于涉及T型钙通道的紊乱和疾病的治疗或预防是有用的。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在涉及T型钙通道的疾病的预防或治疗中的使用。
• HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS
  申请人：Barrow James C.

  公开号：US20100249176A1

  公开（公告）日：2010-09-30

  The present invention is directed to heterocycle amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及杂环酰胺化合物，其是T型钙通道的拮抗剂，并且在治疗或预防涉及T型钙通道的疾病和疾病方面具有用途。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗涉及T型钙通道的疾病方面使用这些化合物和组合物。
• HETEROCYCLE PHENYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS
  申请人：Barrow James C.

  公开号：US20100261724A1

  公开（公告）日：2010-10-14

  The present invention is directed to heterocycle phenyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及杂环苯酰胺化合物，其为T型钙通道的拮抗剂，可用于治疗或预防涉及T型钙通道的疾病和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及T型钙通道的疾病中的使用。