Methyl 2-[(2-phenylsulfanylacetyl)amino]thiophene-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: Methyl 2-[(2-phenylsulfanylacetyl)amino]thiophene-3-carboxylate
• 化学式: C₁₄H₁₃NO₃S₂
• 分子量: 307.4
• InChiKey: CBWXRQLBGNFJHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING TUBERCULOSIS
  申请人：INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

  公开号：US20150133503A1

  公开（公告）日：2015-05-14

  The present invention relates to a pharmaceutical composition for preventing or treating tuberculosis, comprising: (a) a pharmaceutically effective amount of a compound represented by the following chemical formula 1; and (b) a pharmaceutically acceptable carrier. Chemical formula 1 The compound contained as an active ingredient of the present invention inhibits the expression and activity of CO-DH in tubercle bacillus so as to effectively block the detoxification of carbon monoxide, which is an important survival factor of tubercle bacillus , and is safe for the human body since the compound targets CO-DH which does not exist in the human body. In addition, the compound creates a synergistic effect when combined with a conventional tuberculostatic drug, and thus can be more effective for treating tuberculosis.
• [EN] USE OF AMINOTHIOPHENE DERIVATIVE FOR PREVENTING OR TREATING ISCHEMIC DISEASES<br/>[FR] UTILISATION D'UN DÉRIVÉ D'AMINOTHIOPHÈNE POUR PRÉVENIR OU TRAITER DES MALADIES ISCHÉMIQUES
  申请人：KOREA RES INST CHEM TECH

  公开号：WO2008140214A1

  公开（公告）日：2008-11-20

  [EN] The present invention relates to a use of a novel aminothiophene derivative for preventing or treating an ischemic disease, a composition for preventing or treating an ischemic disease comprising said derivative, and a method of preventing or treating an ischemic disease in a mammal comprising administering to the mammal said derivative.
  [FR] La présente invention concerne l'utilisation d'un nouveau dérivé d'aminothiophène pour prévenir ou traiter une maladie ischémique, une composition servant à prévenir ou à traiter une maladie ischémique et comprenant ledit dérivé, ainsi qu'une méthode de prévention ou de traitement d'une maladie ischémique chez un mammifère, qui consiste à administrer ledit dérivé au mammifère.