三氯化铟 | 50800-85-6

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 后过渡金属盐
• 中文名称: 三氯化铟
• 中文别名: In-111氯化铟；盐酸茚地司琼
• 英文名称: INDICLOR
• 英文别名: Indium IN-111 chloride；trichloro(111In)indigane
• CAS: 50800-85-6
• 化学式: Cl₃In
• 分子量: 217.359
• InChiKey: PSCMQHVBLHHWTO-FZTWWWDYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  -9.37
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

ADMET

代谢

铟In-111氯化物是一种放射性示踪剂，用于标记某些制剂中的单克隆抗体，如OncoScint、ProstaScint和Zevalin。其代谢与最终产品相关，而不仅仅是铟In-111氯化物本身。

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its metabolism is related to the final product and not specific to Indium In-111 Chloride alone

来源:DrugBank

毒理性

• 毒性总结

铟-111氯化物是一种用于标记某些制剂中单克隆抗体的放射性示踪剂，例如OncoScint、ProstaScint和Zevalin。其毒性与其最终产品有关，并非特定于铟-111氯化物本身。

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its toxicity is related to the final product and not specific to Indium In-111 Chloride alone

来源:DrugBank

毒理性

• 蛋白质结合

铟In-111氯化物是一种放射性示踪剂，用于标记某些制剂中的单克隆抗体，如OncoScint、ProstaScint和Zevalin。其蛋白质结合与最终产品相关，不仅仅特定于铟In-111氯化物本身。

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its protein binding is related to the final product and not specific to Indium In-111 Chloride alone

来源:DrugBank

吸收、分配和排泄

• 吸收

Indium In-111 Chloride 是一种放射性示踪剂，用于标记某些制剂中的单克隆抗体，如 OncoScint、ProstaScint 和 Zevalin。其吸收与最终产品有关，不仅仅特定于 Indium In-111 Chloride 本身。

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its absoption is related to the final product and not specific to Indium In-111 Chloride alone

来源:DrugBank

吸收、分配和排泄

• 消除途径

铟-111氯化物是一种用于标记单克隆抗体的放射性示踪剂，用于某些制剂，如OncoScint、ProstaScint和Zevalin。其消除途径与最终产品相关，并不仅限于铟-111氯化物本身。

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Itsroute of elimination is related to the final product and not specific to Indium In-111 Chloride alone

来源:DrugBank

吸收、分配和排泄

• 分布容积

铟-111氯化物是一种用于标记单克隆抗体的放射性示踪剂，在某些制剂中，如OncoScint、ProstaScint和Zevalin中有所应用。其分布体积与最终产品相关，并非专指铟-111氯化物本身。

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its volume of distribution is related to the final product and not specific to Indium In-111 Chloride alone

来源:DrugBank

吸收、分配和排泄

• 清除

111铟氯化物是一种用于标记单克隆抗体的放射性示踪剂，用于某些制剂，如OncoScint、ProstaScint和Zevalin。其清除与最终产品有关，不仅仅特定于111铟氯化物。

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its clearance is related to the final product and not specific to Indium In-111 Chloride alone

来源:DrugBank

反应信息

• 作为反应物：
  描述：

  三氯化铟 、 (S)-2,2′-(4-(2-((5-(4-(4-bromophenyl)butanamido)-1-carboxypentyl)amino)-2-oxoethyl)-10-(2-oxo-2-((4-(2-sulfamoylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)phenyl)amino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)-diacetic acid 以 二甲基亚砜 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Modulation of the Pharmacokinetics of a Radioligand Targeting Carbonic Anhydrase-IX with Albumin-Binding Moieties

  摘要：

  DOI：

  10.1021/acs.molpharmaceut.0c00953

文献信息

• Fluorescent gallium and indium bis(thiosemicarbazonates) and their radiolabelled analogues: Synthesis, structures and cellular confocal fluorescence imaging investigations
  作者：Rory L. Arrowsmith、Philip A. Waghorn、Michael W. Jones、Andreas Bauman、Simon K. Brayshaw、Zhiyuan Hu、Gabriele Kociok-Köhn、Thomas L. Mindt、Rex M. Tyrrell、Stanley W. Botchway、Jonathan R. Dilworth、Sofia I. Pascu

  DOI：10.1039/c1dt10126a

  日期：——

  New fluorescent and biocompatible aromatic Ga(III)- and In(III)-bis(thiosemicarbazonato) complexes for dual mode optical and PET or SPECT molecular imaging have been synthesised via a synthetic method based on transmetallation reactions from Zn(II) precursors. Complexes have been fully characterised in the solid state by single crystal X-ray diffraction and in solution by spectroscopic methods (UV/Vis, fluorescence, 1H and 13C1H} NMR). The bis(thiosemicarbazones) radiolabelled rapidly in high yields under mild conditions with 111In (a gamma and Auger emitter for SPECT imaging and radiotherapy with t1/2 = 2.8 d) and 68Ga (a generator-available positron emitter for PET imaging with t1/2 = 68 min). Cytotoxicity and biolocalisation studies using confocal fluorescence imaging and fluorescence lifetime imaging (FLIM) techniques have been used to study their in vitro activities and stabilities in HeLa and PC-3 cells to ascertain their suitability as synthetic scaffolds for future multimodality molecular imaging in cancer diagnosis and therapy. The observation that the indium complexes show certain nuclear uptake could be of relevance towards developing 111In therapeutic agents based on Auger electron emission to induce DNA damage.

  新型荧光和生物相容性芳香族Ga(III)和In(III)双(氨基硫代半卡巴脒)配合物已通过基于从Zn(II)前体进行的金属转移反应的合成方法合成，适用于双模式光学和PET或SPECT分子成像。配合物在固态下通过单晶X射线衍射和在溶液中通过光谱方法（UV/Vis、荧光、1H和13C1H} NMR）进行了全面表征。双(氨基硫代半卡巴脒)在温和条件下快速高效地进行111In（用于SPECT成像和放射治疗的γ和俄歇发射体，t1/2 = 2.8 d）和68Ga（用于PET成像的发生器可用正电子发射体，t1/2 = 68 min）的放射性标记。采用共聚焦荧光成像和荧光寿命成像(FLIM)技术进行的细胞毒性和生物定位研究，用于研究它们在HeLa和PC-3细胞中的体外活性和稳定性，以确定它们作为未来癌症诊断和治疗中多模式分子成像合成骨架的适用性。观察到铟配合物显示出一定的核摄取，这对于开发基于俄歇电子发射诱导DNA损伤的111In治疗剂可能具有相关性。
• Metallic radionuclide-labeled tetrameric 2,6-diisopropylphenyl azides for cancer treatment
  作者：Yudai Ode、Ambara R. Pradipta、Akihiro Ishiwata、Akihiro Nambu、Kazunobu Ohnuki、Hiroshi Mizuma、Hiromitsu Haba、Katsunori Tanaka

  DOI：10.1039/d4cc00048j

  日期：——

  Oligomeric 2,6-diisopropylphenyl azides, equipped with chelators to form stable complexes with metallic radionuclides, were developed as a new radionuclide therapy method that takes advantage of endogenous acrolein overproduced by cancer cells.

  2,6- 二异丙基苯基叠氮化物的低聚体配有螯合剂，可与金属放射性核素形成稳定的络合物，被开发为一种新的放射性核素治疗方法，可利用癌细胞过量产生的内源性丙烯醛。
• Motional freedom of the central metal atom in apohemoglobin reconstituted with¹¹¹In: protoporphyrin IX. Time‐differential perturbed gamma‐ray angular correlations
  作者：Alan G. Marshall、Kai Mon Lee、Peter W. Martin

  DOI：10.1063/1.444843

  日期：1983.2

  Based on time-differential perturbed gamma–gamma angular correlations (PAC), the rotational correlation time for indium-111 in apohemoglobin reconstituted with 111In:protoporphyrin IX is τrot(Hb)=23 ns. For 111In:mesoprotoporphyrin IX reconstituted similarly into apomyoglobin, PAC measurements yield τrot(Mb)=16 ns. The PAC ratio τrot(Hb)/τrot(Mb)=1.4 is the same (within experimental error) as that from fluorescence polarization (FP) measurements for apo-Hb and apo-Mb reconstituted with an aminonaphthalene sulfonate in place of the natural heme. Since the rigid-sphere ratio τrot(Hb)/τrot (Mb)=4.0 is larger than the experimental PAC and FP ratios, the metalloporphyrin exhibits significantly more internal motional freedom in hemoglobin than in myoglobin. Finally, PAC quadrupolar asymmetry parameter values show that the electron distribution about the central metal atom is axially symmetric in reconstituted In–Mb, but not in reconstituted In–Hb.