trans-2-ethyl-7-methylazepane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环庚烷
• 英文名称: trans-2-ethyl-7-methylazepane
• 英文别名: (2R,7R)-2-ethyl-7-methylazepane
• 化学式: C₉H₁₉N
• 分子量: 141.257
• InChiKey: BLUPWFACFHJPQF-RKDXNWHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-Benzyl-7-methylazepane-2-carbonitrile 在 盐酸 、 高氯酸 作用下， 以 四氢呋喃 为溶剂， 生成 trans-2-ethyl-7-methylazepane
  参考文献：
  名称：

  Structure of Alkaloid 275A, a Novel 1-Azabicyclo[5.3.0]decane from a Dendrobatid Frog, Dendrobates lehmanni:  Synthesis of the Tetrahydrodiastereomers

  摘要：

  The principal alkaloid 275A in skins of the Colombian poison frog Dendrobates lehmanni has been identified as the pyrrolo[1,2-alpha ]azepane (1), the first occurrence in nature of this "izidine" system. Tetrahydro-l proved identical to one of the four synthetic diastereomers, 2a-2d, thereby establishing that 1 has the 5Z,10E relative stereochemistry. Alkaloid 1 is often accompanied by other congeners, in particular a 5Z,10Z diastereomer 15, a dihydro analogue 16, and a ketone 17. Such izidines in frogs may arise from dietary ants, as do other classes of izidines.

  DOI：

  10.1021/np0005098

文献信息

• Structure of Alkaloid 275A, a Novel 1-Azabicyclo[5.3.0]decane from a Dendrobatid Frog, <i>Dendrobates </i><i>l</i><i>ehmanni</i>:  Synthesis of the Tetrahydrodiastereomers
  作者：H. Martin Garraffo、Poonam Jain、Thomas F. Spande、John W. Daly、Tappey. H. Jones、Lance J. Smith、Victor E. Zottig

  DOI：10.1021/np0005098

  日期：2001.4.1

  The principal alkaloid 275A in skins of the Colombian poison frog Dendrobates lehmanni has been identified as the pyrrolo[1,2-alpha ]azepane (1), the first occurrence in nature of this "izidine" system. Tetrahydro-l proved identical to one of the four synthetic diastereomers, 2a-2d, thereby establishing that 1 has the 5Z,10E relative stereochemistry. Alkaloid 1 is often accompanied by other congeners, in particular a 5Z,10Z diastereomer 15, a dihydro analogue 16, and a ketone 17. Such izidines in frogs may arise from dietary ants, as do other classes of izidines.