(3S)-N,1-di(propan-2-yl)piperidin-3-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3S)-N,1-di(propan-2-yl)piperidin-3-amine
• 化学式: C₁₁H₂₄N₂
• 分子量: 184.32
• InChiKey: TUOPOOKCDKVDGP-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• IMIDAZOLE AND TRIAZOLE CONTAINING BICYCLIC COMPOUNDS AS JAK INHIBITORS
  申请人：THERAVANCE BIOPHARMA R&D IP, LLC

  公开号：US20200231590A1

  公开（公告）日：2020-07-23

  The invention provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal and other inflammatory diseases.

  这项发明提供了式(I)的化合物： 或其药用可接受的盐，其中变量在规范中定义，这些化合物是JAK激酶的抑制剂，特别是JAK3。该发明还提供了包括这些化合物的药物组合物，以及使用这些化合物治疗胃肠道和其他炎症性疾病的方法。
• Imidazole and triazole containing bicyclic compounds as JAK inhibitors
  申请人：THERAVANCE BIOPHARMA R&D IP, LLC

  公开号：US10851102B2

  公开（公告）日：2020-12-01

  The invention provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal and other inflammatory diseases.

  本发明提供了式(I)化合物：或其药学上可接受的盐，其中变量在说明书中定义，它们是JAK激酶，特别是JAK3的抑制剂。 本发明还提供了包含此类化合物的药物组合物，以及使用此类化合物治疗胃肠道疾病和其他炎症性疾病的方法。
• SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES
  申请人：St. Jude Children's Research Hospital

  公开号：US20190300499A1

  公开（公告）日：2019-10-03

  The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR
  申请人：ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

  公开号：US20210023081A1

  公开（公告）日：2021-01-28

  The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.