乙基1,2,4-三嗪-5-羧酸酯 | 143209-28-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 中文名称: 乙基1,2,4-三嗪-5-羧酸酯
• 英文名称: Ethyl 1,2,4-triazine-5-carboxylate
• CAS: 143209-28-3
• 化学式: C₆H₇N₃O₂
• 分子量: 153.14
• InChiKey: OPBDVDRIPDMBIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  65
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• BIARYLUREA DERIVATIVES
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1199306A1

  公开（公告）日：2002-04-24

  The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: ,wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula --- is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.

  本发明涉及一种式（I）化合物及其制造方法和用途： 其中Ar为含氮杂芳环基团；X和Z各为碳原子，以此类推；Y为CO，以此类推；R1为氢原子，以此类推；R2和R3各为氢原子，以此类推；R4和R5各为氢原子，以此类推；式中----为单键或双键。 根据本发明，本发明化合物可以提供用于治疗恶性肿瘤的Cdk4和/或Cdk6抑制剂，因为本发明化合物对肿瘤细胞表现出突出的生长抑制活性。
• Biarylurea Derivatives
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1557168A2

  公开（公告）日：2005-07-27

  The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: ,wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.

  本发明涉及一种式（I）化合物及其制造方法和用途： 其中Ar为含氮杂芳环基团；X和Z各为碳原子，以此类推；Y为CO，以此类推；R1为氢原子，以此类推；R2和R3各为氢原子，以此类推；R4和R5各为氢原子，以此类推；式中为单键或双键。 根据本发明，本发明化合物可以提供用于治疗恶性肿瘤的 Cdk4 和/或 Cdk6 抑制剂，因为本发明化合物对肿瘤细胞具有突出的生长抑制活性。
• Biarylurea derivatives
  申请人：Hayama Takashi

  公开号：US20070027147A1

  公开（公告）日：2007-02-01

  The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R 1 is a hydrogen atom, and so on; R 2 and R 3 are each a hydrogen atom, and so on; R 4 and R 5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.
• US6958333B1
  申请人：——

  公开号：US6958333B1

  公开（公告）日：2005-10-25
• US7354946B2
  申请人：——

  公开号：US7354946B2

  公开（公告）日：2008-04-08