2-((8Z,11Z)-heptadeca-8,11-dien-1-yl)-4,4-dimethyl-4,5-dihydrooxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 2-((8Z,11Z)-heptadeca-8,11-dien-1-yl)-4,4-dimethyl-4,5-dihydrooxazole
• 英文别名: cis-9, cis-12-Octadecadienoic acid, 4,4-dimethyloxazoline (dmox) derivative；2-[(8Z,11Z)-heptadeca-8,11-dienyl]-4,4-dimethyl-5H-1,3-oxazole
• 化学式: C₂₂H₃₉NO
• 分子量: 333.558
• InChiKey: GBLPZQMYSCGEAK-MURFETPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  24
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (Z,Z)-9,12-十八烷二烯酸二聚物 、 2-氨基-2-甲基-1-丙醇 在 [双(2-甲氧基乙基)胺]三氟化硫 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以96%的产率得到2-((8Z,11Z)-heptadeca-8,11-dien-1-yl)-4,4-dimethyl-4,5-dihydrooxazole
  参考文献：
  名称：

  One pot direct synthesis of amides or oxazolines from carboxylic acids using Deoxo-Fluor reagent

  摘要：

  A mild and highly efficient one pot-one step condensation and/or condensation-cyclization of various acids to amides and/or oxazolines using Deoxo-Fluor reagents is described. Parallel syntheses of various free fatty acids with 2-amino-2, 2-dimethyl-1-propanol resulted with excellent yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.10.068

文献信息

• LINOLEIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION OR FOOD COMPOSITION COMPRISING SAID LINOLEIC ACID DERIVATIVES, AND THEIR USES
  申请人：Université de Bourgogne

  公开号：EP3802482A1

  公开（公告）日：2021-04-14
• One pot direct synthesis of amides or oxazolines from carboxylic acids using Deoxo-Fluor reagent
  作者：Cyrous O. Kangani、David E. Kelley

  DOI：10.1016/j.tetlet.2005.10.068

  日期：2005.12

  A mild and highly efficient one pot-one step condensation and/or condensation-cyclization of various acids to amides and/or oxazolines using Deoxo-Fluor reagents is described. Parallel syntheses of various free fatty acids with 2-amino-2, 2-dimethyl-1-propanol resulted with excellent yields. (c) 2005 Elsevier Ltd. All rights reserved.