rhynchophylline | 151124-30-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚里西啶
• 英文名称: rhynchophylline
• 英文别名: (7R,16E)-17-methoxy-2-oxo-20βH-corynox-16-ene-16-carboxylic acid；(7R,16E)-17-Methoxy-2-oxo-20βH-corynox-16-en-16-carbonsaeure；(E)-2-[(3R,6'R,7'S,8'aS)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoic acid
• CAS: 151124-30-0
• 化学式: C₂₁H₂₆N₂O₄
• 分子量: 370.448
• InChiKey: IQSFEAHJUMVILC-UIQGJUIRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 rhynchophylline
  参考文献：
  名称：

  Kondo; Ikeda, Yakugaku Zasshi, 1937, vol. 57, p. 881,885;dtsch.Ref.S.238,241

  摘要：

  DOI：

文献信息

• [EN] EphA4 INHIBITORS AS NEUROPROTECTIVE AGENTS<br/>[FR] INHIBITEURS D'EPHA4 EN TANT QU'AGENTS NEUROPROTECTEURS
  申请人：UNIV HONG KONG SCIENCE & TECHN

  公开号：WO2015007222A1

  公开（公告）日：2015-01-22

  Provided is the discovery of the role of EphA4 signaling in neurodegenerative disorders involving β-amyloid induced neurotoxicity such as Alzheimer's Disease. New therapeutic methods, therapeutic agents, and kits for treating diseases caused or exacerbated by overactivated EphA4 signaling are provided. Also provided are methods for identifying additional compounds as therapeutic agents useful for treating conditions involving overly active EphA4 signaling.

  提供了EphA4信号在涉及β-淀粉样蛋白诱导的神经毒性等神经退行性疾病中的作用发现，如阿尔茨海默病。提供了用于治疗由过度活化的EphA4信号引起或加重的疾病的新疗法、治疗剂和工具。还提供了用于识别额外化合物作为治疗剂，对治疗涉及过度活跃的EphA4信号的条件有用的方法。
• EphA4 INHIBITORS AS NEUROPROTECTIVE AGENTS
  申请人：THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

  公开号：US20160152618A1

  公开（公告）日：2016-06-02

  Provided is the discovery of the role of EphA4 signaling in neurodegenerative disorders involving β-amyloid induced neurotoxicity such as Alzheimer's Disease. New therapeutic methods, therapeutic agents, and kits for treating diseases caused or exacerbated by overactivated EphA4 signaling are provided. Also provided are methods for identifying additional compounds as therapeutic agents useful for treating conditions involving overly active EphA4 signaling.
• US9629830B2
  申请人：——

  公开号：US9629830B2

  公开（公告）日：2017-04-25
• Kondo; Ikeda, Yakugaku Zasshi, 1937, vol. 57, p. 881,885;dtsch.Ref.S.238,241
  作者：Kondo、Ikeda

  DOI：——

  日期：——
• THE ALKALOIDS OF MITRAGYNA ROTUNDIFOLIA. I
  作者：GEORGE BARGER、ELIZABETH DYER、LEWIS J. SARGENT

  DOI：10.1021/jo01216a008

  日期：1939.9