3-chloropropyl dichloromethylsilane

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: 3-chloropropyl dichloromethylsilane
• 英文别名: 3-Chloropropyl dichloromethylsilane；3-chloropropyl(dichloromethyl)silane
• 化学式: C₄H₉Cl₃Si
• 分子量: 191.56
• InChiKey: RJUYTLBXBVBQGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.96
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  3-chloropropyl dichloromethylsilane 、 乙烯基氯化镁 以 四氢呋喃 为溶剂， 以91%的产率得到正己烷
  参考文献：
  名称：

  Surface Modified Organic Inorganic Hybrid Glass, Protecting Group Induced Alcohol or Its Derivative and Producing Method Thereof

  摘要：

  本文揭示了一种受保护的醇或其衍生物、一种表面改性的有机-无机混合玻璃及其制备方法。更具体地，本文揭示了一种受保护的醇或其衍生物以及一种表面改性的有机-无机混合玻璃，通过让具有乙烯或乙烯衍生物的硅烷化合物在酸催化剂、过渡金属催化剂和有机溶剂的存在下与醇或其衍生物或有机-无机混合玻璃发生反应，从而在室温下引入有机基团，以及其制备方法。本发明允许在醇或其衍生物或有机-无机混合玻璃中有效引入功能基团，不仅在高温下，而且在室温下，因此在引入具有热敏功能基团的化合物方面非常有效，例如天然化合物或蛋白质。此外，该发明使得可以引入各种有机基团，并且利用硅胶柱分离和纯化有机大分子结合的有机硅烷化合物，从而有效地将大有机功能基团引入无机材料中。因此，该发明在化学工业中具有非常高的实用性。

  公开号：

  US20090274910A1

文献信息

• Surface Modified Inorganic Material and Producing Method Thereof
  申请人：Jun Chul-Ho

  公开号：US20090270590A1

  公开（公告）日：2009-10-29

  A surface-modified inorganic material and a preparation method thereof. A surface-modified inorganic material is provided which is obtained by allowing an organosilane compound having allyl or an allyl derivative to react with an inorganic material, particularly solid silica or ITO glass, in the presence of an acid and an organic solvent, to introduce an organic group into the inorganic material even at room temperature, as well as a preparation method thereof. The invention can effectively introduce the organic group into the inorganic material even at room temperature, and thus is very effective in introducing compounds having a thermally sensitive functional group, for example, natural compounds or proteins. It is possible to introduce various organic groups into an inorganic material and to separate and purify organic molecule-bonded organosilane compounds using a silica gel column to effectively bond them to inorganic materials. Accordingly, the invention is very useful in the chemical industry.

  提供了一种表面改性的无机材料及其制备方法。通过在有机溶剂和酸的存在下，让具有烯丙基或烯丙基衍生物的有机硅化合物与无机材料（特别是固体二氧化硅或ITO玻璃）反应，即使在室温下也能将有机基团引入无机材料中，从而获得表面改性的无机材料。该发明能够在室温下有效地将有机基团引入无机材料中，因此对于引入具有热敏感功能基团的化合物（例如天然化合物或蛋白质）非常有效。可以将各种有机基团引入无机材料中，并使用硅胶柱分离和纯化有机分子键合的有机硅化合物，从而有效地将它们与无机材料键合。因此，该发明在化学工业中非常有用。
• Surface modified organic inorganic hybrid glass, protecting group induced alcohol or its derivative and producing method thereof
  申请人：Industry-Academic Cooperation Foundation Yonsei University

  公开号：US08197903B2

  公开（公告）日：2012-06-12

  Disclosed are a protected alcohol or derivative thereof, a surface-modified organic-inorganic hybrid glass, and preparation methods thereof. More specifically, disclosed are a protected alcohol or derivative thereof and a surface-modified organic-inorganic hybrid glass, which are prepared by allowing a silane compound, having vinyl or a vinyl derivative, to react with an alcohol or derivative thereof or with an organic-inorganic hybrid glass, in the presence of an acid catalyst, a transition metal catalyst and an organic solvent, so as to introduce an organic group thereto even at room temperature, as well as preparation methods thereof. The disclosed invention allows a functional group to be effectively introduced into alcohol or a derivative thereof or into an organic-inorganic hybrid glass, not only high temperatures but also room temperature, and thus is highly effective in introducing compounds having a thermally sensitive functional group, for example, natural compounds or proteins. Also, the invention makes it possible to introduce various organic groups and to separate and purify organic macromolecule-bonded organosilane compounds using a silica gel column so as to effectively introduce large organic functional groups to inorganic materials. Accordingly, the invention is highly useful in the chemical industry.

  本发明涉及一种保护的醇或其衍生物、表面改性的有机-无机杂化玻璃及其制备方法。具体而言，本发明涉及一种通过在酸催化剂、过渡金属催化剂和有机溶剂的存在下，让具有乙烯或乙烯衍生物的硅烷化合物与醇或其衍生物或有机-无机杂化玻璃反应，以便即使在室温下引入有机基团的保护醇或其衍生物或有机-无机杂化玻璃以及其制备方法。本发明不仅可以在高温下，而且可以在室温下有效地引入功能基团到醇或其衍生物或有机-无机杂化玻璃中，因此在引入具有热敏功能基团的化合物，例如天然化合物或蛋白质时具有高效性。此外，本发明使得引入各种有机基团成为可能，并且可以使用硅胶柱分离和纯化有机大分子键合的有机硅烷化合物，以便将大的有机功能基团有效地引入无机材料中。因此，本发明在化学工业中具有高度的实用性。
• SURFACE MODIFIED INORGANIC MATERIAL AND PRODUCING METHOD THEREOF
  申请人：Jun Chul-Ho

  公开号：US20130060014A1

  公开（公告）日：2013-03-07

  A surface-modified inorganic material and a preparation method thereof. A surface-modified inorganic material is provided which is obtained by allowing an organosilane compound having allyl or an allyl derivative to react with an inorganic material, particularly solid silica or ITO glass, in the presence of an acid and an organic solvent, to introduce an organic group into the inorganic material even at room temperature, as well as a preparation method thereof. The invention can effectively introduce the organic group into the inorganic material even at room temperature, and thus is very effective in introducing compounds having a thermally sensitive functional group, for example, natural compounds or proteins. It is possible to introduce various organic groups into an inorganic material and to separate and purify organic molecule-bonded organosilane compounds using a silica gel column to effectively bond them to inorganic materials.

  提供了一种表面改性的无机材料及其制备方法。通过在酸和有机溶剂的存在下，使具有烯丙基或烯丙基衍生物的有机硅化合物与无机材料，特别是固体二氧化硅或ITO玻璃反应，即使在室温下也能将有机基团引入无机材料中，从而得到表面改性的无机材料及其制备方法。该发明能够有效地将有机基团引入无机材料中，即使在室温下也能实现，因此非常适合引入具有热敏功能基团的化合物，例如天然化合物或蛋白质。可以将各种有机基团引入无机材料中，并使用硅胶柱分离和纯化有机分子-键合的有机硅化合物，以有效地将它们键合到无机材料上。
• Surface Modified Organic Inorganic Hybrid Glass, Protecting Group Induced Alcohol or Its Derivative and Producing Method Thereof
  申请人：Jun Chul-Ho

  公开号：US20090274910A1

  公开（公告）日：2009-11-05

  Disclosed are a protected alcohol or derivative thereof, a surface-modified organic-inorganic hybrid glass, and preparation methods thereof. More specifically, disclosed are a protected alcohol or derivative thereof and a surface-modified organic-inorganic hybrid glass, which are prepared by allowing a silane compound, having vinyl or a vinyl derivative, to react with an alcohol or derivative thereof or with an organic-inorganic hybrid glass, in the presence of an acid catalyst, a transition metal catalyst and an organic solvent, so as to introduce an organic group thereto even at room temperature, as well as preparation methods thereof. The disclosed invention allows a functional group to be effectively introduced into alcohol or a derivative thereof or into an organic-inorganic hybrid glass, not only high temperatures but also room temperature, and thus is highly effective in introducing compounds having a thermally sensitive functional group, for example, natural compounds or proteins. Also, the invention makes it possible to introduce various organic groups and to separate and purify organic macromolecule-bonded organosilane compounds using a silica gel column so as to effectively introduce large organic functional groups to inorganic materials. Accordingly, the invention is highly useful in the chemical industry.

  本文揭示了一种受保护的醇或其衍生物、一种表面改性的有机-无机混合玻璃及其制备方法。更具体地，本文揭示了一种受保护的醇或其衍生物以及一种表面改性的有机-无机混合玻璃，通过让具有乙烯或乙烯衍生物的硅烷化合物在酸催化剂、过渡金属催化剂和有机溶剂的存在下与醇或其衍生物或有机-无机混合玻璃发生反应，从而在室温下引入有机基团，以及其制备方法。本发明允许在醇或其衍生物或有机-无机混合玻璃中有效引入功能基团，不仅在高温下，而且在室温下，因此在引入具有热敏功能基团的化合物方面非常有效，例如天然化合物或蛋白质。此外，该发明使得可以引入各种有机基团，并且利用硅胶柱分离和纯化有机大分子结合的有机硅烷化合物，从而有效地将大有机功能基团引入无机材料中。因此，该发明在化学工业中具有非常高的实用性。