n-butyldiisopropylchlorosilane

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: n-butyldiisopropylchlorosilane
• 英文别名: Butyldiisopropyl-chlorosilane；butyl-chloro-di(propan-2-yl)silane
• 化学式: C₁₀H₂₃ClSi
• 分子量: 206.831
• InChiKey: KDLWFURXIWRTJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.79
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  misoprostol 、 n-butyldiisopropylchlorosilane 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 96.0h， 生成 (11α,13E)-11-<oxy>-16-hydroxy-16-methyl-9-oxo-prost-13-en-1-oic acid methyl ester
  参考文献：
  名称：

  Catalytic functionalization of polymers: a novel approach to site-specific delivery of misoprostol to the stomach

  摘要：

  The application of functionalized polymers to site-directed delivery of the antiulcer prostaglandin, misoprostol, is described. By use of homogeneous catalysis, the simple polymer, polybutadiene, was modified to incorporate the specialized requirements for controlled delivery of misoprostol to the stomach. An acid labile silyl ether bond to the C-11 hydroxyl of misoprostol was installed as the primary rate determining step for drug release, and a series of analogs, in which the steric hindrance about the silicon atom was varied, was prepared and evaluated for in vitro release rates, efficacy against indomethacin induced gastric damage and diarrheagenic activity. The diisopropylsilyl analog, the slowest releasing system studied, showed efficacy equal to misoprostol against indomethacin-induced gastric damage and no diarrhea at the highest dose tested.

  DOI：

  10.1021/jm00073a007
• 作为产物：
  描述：

  二异丙基二氯硅烷 、 正丁基锂 以 四氢呋喃 为溶剂， 以to yield butyldiisopropyl-chlorosilane 2, which的产率得到n-butyldiisopropylchlorosilane
  参考文献：
  名称：

  FLAVANTHRENE DERIVATIVES AND THEIR USE AS ORGANIC SEMICONDUCTORS

  摘要：

  本发明涉及苯并[h]苯[5,6]螺[2,1,9,8-klmna]螺吩，它们的制备方法，它们作为有机电子(OE)器件中的半导体的用途，以及包含它们的OE器件。

  公开号：

  US20130306914A1

文献信息

• FLAVANTHRENE DERIVATIVES AND THEIR USE AS ORGANIC SEMICONDUCTORS
  申请人：Wang Changsheng

  公开号：US20130306914A1

  公开（公告）日：2013-11-21

  The invention relates to benzo[h]benz[5,6]acridino[2,1,9,8-klmna]acridines, methods of their preparation, their use as semiconductors in organic electronic (OE) devices, and to OE devices comprising them.

  本发明涉及苯并[h]苯[5,6]螺[2,1,9,8-klmna]螺吩，它们的制备方法，它们作为有机电子(OE)器件中的半导体的用途，以及包含它们的OE器件。
• Foss, V. L.; Veits, Yu. A.; Leksunkin, V. A., Journal of general chemistry of the USSR, 1985, vol. 55, # 7, p. 1458 - 1459
  作者：Foss, V. L.、Veits, Yu. A.、Leksunkin, V. A.、Gurov, M. V.

  DOI：——

  日期：——
• FOSS, V. L.;VEJTS, YU. A.;LEKSUNKIN, V. A.;GUROV, M. V., ZH. OBSHCH. XIMII, 1985, 55, N 7, 1639-1640
  作者：FOSS, V. L.、VEJTS, YU. A.、LEKSUNKIN, V. A.、GUROV, M. V.

  DOI：——

  日期：——
• Catalytic functionalization of polymers: a novel approach to site-specific delivery of misoprostol to the stomach
  作者：Samuel J. Tremont、Paul W. Collins、William E. Perkins、Rick L. Fenton、Denis Forster、Martin P. McGrath、Grace M. Wagner、Alan F. Gasiecki、Robert G. Bianchi

  DOI：10.1021/jm00073a007

  日期：1993.10

  The application of functionalized polymers to site-directed delivery of the antiulcer prostaglandin, misoprostol, is described. By use of homogeneous catalysis, the simple polymer, polybutadiene, was modified to incorporate the specialized requirements for controlled delivery of misoprostol to the stomach. An acid labile silyl ether bond to the C-11 hydroxyl of misoprostol was installed as the primary rate determining step for drug release, and a series of analogs, in which the steric hindrance about the silicon atom was varied, was prepared and evaluated for in vitro release rates, efficacy against indomethacin induced gastric damage and diarrheagenic activity. The diisopropylsilyl analog, the slowest releasing system studied, showed efficacy equal to misoprostol against indomethacin-induced gastric damage and no diarrhea at the highest dose tested.
• Flavanthrene derivatives and their use as organic semiconductors
  申请人：Wang Changsheng

  公开号：US09373801B2

  公开（公告）日：2016-06-21

  The invention relates to benzo[h]benz[5,6]acridino[2,1,9,8-klmna]acridines, methods of their preparation, their use as semiconductors in organic electronic (OE) devices, and to OE devices comprising them.

  本发明涉及苯并[h]苯[5,6]蒽[2,1,9,8-klmna]蒽衍生物、其制备方法、其在有机电子（OE）器件中作为半导体的应用，以及包含它们的OE器件。