amycomycin B

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 角环素
• 英文名称: amycomycin B
• 化学式: C₂₄H₂₀O₁₀
• 分子量: 468.417
• InChiKey: OSKYSCDCKRQEAD-ASUSIWSLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.94
• 重原子数：
  34.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  173.98
• 氢给体数：
  6.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  amycomycin B 在 硫酸 作用下， 以 甲醇 为溶剂， 反应 6.0h， 生成 L-鼠李糖
  参考文献：
  名称：

  Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity

  摘要：

  One new angucyclinone derivative, amycomycin A (1), and one new angucycline, amycomycin B (2), along with 5 known compounds (3-7), were isolated from an actinobacterium Amycolatopsis sp. HCa1 associated with the grasshopper, Oxya chinensis. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 1-7 were tested in vitro for their cytotoxic effects on five cell lines including human gastric adenocarcinoma cell line (BGC823), human hepatocarcinoma cell line (HepG2), human melanoma cell line (A375), human oral squamous carcinoma cell line (KB), and ghost cell line (Ghost-R5X4). Cell viability assays showed that compound 7 was active in four cell lines with IC50 values less than 18.0 mu M except in KB showing no activity up to 100 mu M. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.048

文献信息

• Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity
  作者：Zhi Kai Guo、Shou Bai Liu、Rui Hua Jiao、Ting Wang、Ren Xiang Tan、Hui Ming Ge

  DOI：10.1016/j.bmcl.2012.10.048

  日期：2012.12

  One new angucyclinone derivative, amycomycin A (1), and one new angucycline, amycomycin B (2), along with 5 known compounds (3-7), were isolated from an actinobacterium Amycolatopsis sp. HCa1 associated with the grasshopper, Oxya chinensis. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 1-7 were tested in vitro for their cytotoxic effects on five cell lines including human gastric adenocarcinoma cell line (BGC823), human hepatocarcinoma cell line (HepG2), human melanoma cell line (A375), human oral squamous carcinoma cell line (KB), and ghost cell line (Ghost-R5X4). Cell viability assays showed that compound 7 was active in four cell lines with IC50 values less than 18.0 mu M except in KB showing no activity up to 100 mu M. (C) 2012 Elsevier Ltd. All rights reserved.