(trifluoromethyl)triphenylmethane

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (trifluoromethyl)triphenylmethane
• 英文别名: 1,1,1-Trifluoro-2,2,2-triphenylethane；1,1,1-Triphenyl-2,2,2-trifluoroethane；(2,2,2-trifluoro-1,1-diphenylethyl)benzene
• 化学式: C₂₀H₁₅F₃
• 分子量: 312.334
• InChiKey: DDQFZIYFUHPDAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2,2-三氟苯乙酮 、 苯 在 三氟甲磺酸 作用下， 反应 24.0h， 以100%的产率得到(trifluoromethyl)triphenylmethane
  参考文献：
  名称：

  Condensations of aryl trifluoromethyl ketones with arenes in acidic media

  摘要：

  The chemistry of trifluoromethyl ketones has been studied. The work examines the condensation reactions of trifluoromethyl ketones with arenes in the superacid, including both synthetic and mechanistic aspects. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.07.067

文献信息

• 1,1,1-Triaryl-2,2,2-trifluoroethanes and process for their synthesis
  申请人：——

  公开号：US04307024A1

  公开（公告）日：1981-12-22

  New 1,1,1-triaryl-2,2,2-trifluoroethanes in which the aryl radicals carry one or more substitutents have been prepared by condensation of trifluoroacetophenones with substituted phenyl compounds in the presence of catalytic quantities of trifluoromethylsulfonic acid. The reaction can be carried out under reflux in toluene or, for strikingly better results in certain cases, reactants are simply stirred at room temperature for about 24 to 48 hours.

  新的1,1,1-三芳基-2,2,2-三氟乙烷已经制备出来，其中芳基基团携带一个或多个取代基，通过在三氟甲磺酸催化下，三氟乙酰苯酮与取代苯基化合物缩合反应而成。该反应可以在甲苯中回流进行，或者在某些情况下，反应物在室温下简单搅拌约24至48小时可获得显着更好的结果。
• OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS
  申请人：Hanson Gunnar J.

  公开号：US20120065169A1

  公开（公告）日：2012-03-15

  Oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.

  提供了包含修改的亚单位连接和/或修改的3'和/或5'-末端基团的寡核苷酸类似物。所披露的化合物对于治疗需要抑制蛋白质表达或纠正异常mRNA剪接产物以产生有益治疗效果的疾病非常有用。
• PEPTIDE OLIGONUCLEOTIDE CONJUGATES
  申请人：Hanson Gunnar J.

  公开号：US20120289457A1

  公开（公告）日：2012-11-15

  Oligonucleotide analogues conjugated to carrier peptides are provided. The disclosed compounds are useful for the treatment of various diseases, for example diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.

  提供了与载体肽共轭的寡核苷酸类似物。所公开的化合物可用于治疗各种疾病，例如抑制蛋白质表达或校正异常的mRNA剪接产物可产生有益的治疗效果的疾病。
• dsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups
  申请人：Iversen Patrick L.

  公开号：US10017763B2

  公开（公告）日：2018-07-10

  Morpholino oligomers containing modified intersubunit linkages and/or terminal groups are provided for use within dsRNA molecules. The oligomers are oligonucleotide analogs containing predetermined sequences of base-pairing moieties. Also provided are such oligomers conjugated to peptide transporter moieties, where the transporters are preferably composed of arginine subunits, or arginine dimers, alternating with neutral amino acid subunits.

  Morpholino 寡聚物含有修饰的亚基间连接和/或末端基团，可用于 dsRNA 分子。这些寡聚物是含有预定碱基配对分子序列的寡核苷酸类似物。还提供了与肽转运体分子连接的此类寡聚体，其中转运体最好由精氨酸亚基或精氨酸二聚体组成，与中性氨基酸亚基交替使用。
• Oligonucleotide analogues targeting human LMNA
  申请人：SAREPTA THERAPEUTICS, INC.

  公开号：US10076536B2

  公开（公告）日：2018-09-18

  Provided are LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin.

  本文提供了 LMNA 靶向反义寡核苷酸，用于减少编码早老素的一种或多种异常剪接 LMNA mRNA 异构体的表达。