(3R,4S)-3-methylpiperidine-4-thiol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3R,4S)-3-methylpiperidine-4-thiol
• 化学式: C₆H₁₃NS
• 分子量: 131.24
• InChiKey: QJVCCHIMVYBPDV-RITPCOANSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  13
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• ADO-resistant cysteamine analogs and uses thereof
  申请人：HORIZON ORPHAN LLC

  公开号：US10906904B2

  公开（公告）日：2021-02-02

  The present disclosure is directed to methods for treating diseases for which cysteamine is indicated and compounds useful in such methods.

  本公开涉及治疗半胱胺可用于治疗的疾病的方法以及在这些方法中有用的化合物。
• ADO-RESISTANT CYSTEAMINE ANALOGS AND USES THEREOF
  申请人：Horizon Orphan LLC

  公开号：EP3316877B1

  公开（公告）日：2019-10-30
• [EN] ADO-RESISTANT CYSTEAMINE ANALOGS AND USES THEREOF<br/>[FR] ANALOGUES DE LA CYSTÉAMINE RÉSISTANT À L'ADO ET UTILISATIONS DE CEUX-CI
  申请人：RAPTOR PHARMACEUTICALS INC

  公开号：WO2017004485A1

  公开（公告）日：2017-01-05

  The present invention is directed to ADO-resistant cysteamine analogs for use in methods of treating diseases for which cysteamine is indicated, in particular cystinosis, fatty liver disease, fibrosis, thrombotic diseases, MECP-2 related disorders, inherited mitochondrial diseases, neurological diseases or disorders, inflammation and cancer.