二氯三聚异氰酸钾 | 2244-21-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 中文名称: 二氯三聚异氰酸钾
• 中文别名: 曲氯新钾
• CAS: 2244-21-5
• 化学式: C3HCl2N3O3.K
• 分子量: 237.06
• InChiKey: UGLFQJOXHCQGFQ-UHFFFAOYSA-N

物化性质

• 熔点：
  250°C (rough estimate)
• 物理描述：
  Potassium dichloro-s-triazinetrione, dry is a white solid with an odor of chlorine. Mixes with water. (USCG, 1999)
• 颜色/状态：
  WHITE, CRYSTALLINE POWDER OR GRANULES
• 气味：
  Chlorine-like
• 溶解度：
  10 to 50 mg/mL at 63° F (NTP, 1992)
• 密度：
  0.96 at 20 °C (solid)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.68
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.7
• 氢给体数：
  1
• 氢受体数：
  3

ADMET

毒理性

• 人类毒性摘录

毒性显然是由于对胃粘膜的腐蚀作用，而不是任何系统性影响。在潮湿的环境中，如眼睛、上呼吸道或湿润或磨损的皮肤上，它具有中等刺激性。在一些个体中，吸入粉尘可能会导致支气管痉挛。/三氯异氰尿酸/

The toxicity is apparently due to corrosive action on stomach lining rather than to any systemic effects. In the presence of moisture, as in the eyes, upper respiratory tract or on moist or abraded skin, it is moderately irritating. In some individuals bronchospasm may result from breathing the dust. /Trichloroisocyanuric acid/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

在涂抹干燥粉末状的 sodium (potassium) dichloroisocyanurate 后的24小时内，未观察到对家兔完好皮肤的刺激性。

NO IRRITATION ON THE INTACT SKIN OF RABBITS WAS OBSERVED AFTER APPLICATION OF SODIUM (POTASSIUM) DICHLOROISOCYANURATE IN THE FORM OF DRY POWDER FOR 24 HR.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

当一只兔子的一个眼睛暴露于流动的大约330毫升/小时、每天1小时、每周5天、总共30次暴露的3毫克/升有效氯的次氯酸二氢钾溶液(3 PPM AS AVAILABLE CHLORINE)时，没有报告出现显著刺激性。

NO SIGNIFICANT IRRITATION WAS REPORTED WHEN ONE EYE OF A RABBIT WAS EXPOSED TO SOLN OF POTASSIUM DICHLOROISOCYANURATE (3 PPM AS AVAILABLE CHLORINE) FLOWING AT APPROX 330 ML/HR, 1 HR/DAY, 5 DAYS/WK, FOR TOTAL OF 30 EXPOSURES.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• TSCA 测试提交

二氯异氰尿酸钾盐（CAS# 2244-21-5）的急性口服毒性进行了评估。试验物质口服给予斯普拉格-道利白化大鼠。剂量水平和死亡率数据如下：1000毫克/千克体重（0/2雄性，1/3雌性）；1260毫克/千克体重（0/3雄性，2/2雌性）；1580毫克/千克体重（1/2雄性，3/3雌性）；2000毫克/千克体重（3/3雄性，2/2雌性），大多数死亡发生在2天内。临床表现包括食欲和活动减少，逐渐虚弱，倒下，死亡。尸检发现肺部有出血区域，肝脏变色，以及急性胃肠炎。LD50确定为1400毫克/千克体重。

Dichloroisocyanurate, potassium salt (CAS# 2244-21-5) was evaluated for acute oral toxicity. The test substance was administered orally to Sprague-Dawley albino rats. Dosage levels and mortality data are as follows: 1000 (0/2 M, 1/3 F); 1260 (0/3 M, 2/2 F); 1580 (1/2 M, 3/3 F); and 2000 mg/kg of body weight (3/3 M, 2/2 F), with most deaths occurring within 2 days. Clinical signs included reduced appetite and activity, increasing weakness, collapse, and death. Necropsy findings revealed hemorrhagic areas of the lungs, liver discoloration, and acute gastrointestinal inflammation. The LD50 was determined to be 1400 mg/kg b.w.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• TSCA 测试提交

二氯异氰尿酸钾盐（CAS# 2244-21-5）的急性皮肤毒性进行了评估。试验物质涂抹于新西兰白兔的皮肤上，持续24小时。剂量水平和死亡率数据如下：1260毫克/千克体重（0/1公兔）；2000毫克/千克体重（0/1母兔）；3160毫克/千克体重（1/1公兔，4天内死亡）；5010毫克/千克体重（1/1母兔，3天内死亡）。临床体征包括食欲和活动减少，逐渐虚弱，倒下，死亡。尸检发现肺部和肝脏有出血区域，胆囊肿大，胃肠道炎症。LD50（致死剂量中值）确定为大于2000毫克/千克体重。

Dichloroisocyanurate, potassium salt (CAS# 2244-21-5) was evaluated for acute dermal toxicity. The test substance was applied to the skin of New Zealand albino rabbits for 24-hours. Dosage levels and mortality data are as follows: 1260 (0/1 M); 2000 (0/1 F); 3160 (1/1 M in 4-days); and 5010 mg/kg b.w. (1/1 F in 3-days). Clinical signs included reduced appetite and activity, increasing weakness, collapse, and death. Necropsy findings revealed hemorrhagic areas of the lungs and liver, enlarged gall bladder, and gastrointestinal inflammation. The LD50 was determined to be greater than 2,000 mg/kg b.w.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  5.1
• 包装等级：
  II
• 危险类别：
  5.1