5-[2-(4-Methylphenyl)-2-phenylvinyl]-N-triphenylmethyltetrazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5-[2-(4-Methylphenyl)-2-phenylvinyl]-N-triphenylmethyltetrazole
• 英文别名: 5-[(E)-2-(4-methylphenyl)-2-phenylethenyl]-1-trityltetrazole
• 化学式: C₃₅H₂₈N₄
• 分子量: 504.634
• InChiKey: XEJKIBHVIGSNGQ-MHTZHOPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  三苯基氯甲烷 在 三乙胺 作用下， 以 丙酮 为溶剂， 以71%的产率得到5-[2-(4-Methylphenyl)-2-phenylvinyl]-N-triphenylmethyltetrazole
  参考文献：
  名称：

  New imidazopyridine derivatives as angiotensin II antagonists

  摘要：

  本发明涉及公式I的新咪唑吡啶衍生物，其中：A、B、C和D中的一个为N，另外三个为CR，其中每个R独立地代表氢、C1-4烷基、COOH或卤素；R1代表C1-4烷基或C3-7环烷基；Ar1代表苯基或吡啶基，可以选择性地被取代；V代表C1-4烷基、C3-7环烷基、芳基、芳基-(C1-4)烷基或5-或6-成员芳香杂环；X-Y基团代表C = C或CH-CR3；R3代表氢、C1-4烷基或芳基-(C1-4)烷基；Z代表等等的基团之一，如-CO2R4、-四唑-5-基、-CONHSO2R4、-CONR4R5、-CH2NHSO2R4；R4和R5独立地代表氢、C1-4烷基、芳基、芳基-(C1-4)烷基或全氟-(C1-4)烷基；W代表氢、氰基、C1-4烷基、C1-4卤代烷基、C3-7环烷基、芳基、芳基-(C1-4)烷基、C1-4烷基磺酰基、C1-4烷基亚砜基、C1-4烷基硫基、C1-4烷氧基、C1-4烷基羰基、卤素、羟甲基或C1-4烷氧甲基，或W可以具有Z所披露的任何含义。这些化合物是血管紧张素II拮抗剂。

  公开号：

  EP0669333A1

文献信息

• New imidazopyridine derivatives as angiotensin II antagonists
  申请人：J. URIACH & CIA. S.A.

  公开号：EP0669333A1

  公开（公告）日：1995-08-30

  The present invention relates to new imidazopyridine derivatives of formula I wherein: one of A, B, C and D is N and the other are CR, wherein each R independently represents hydrogen, C1-4 alkyl, COOH or halogen; R1 represents C1-4 alkyl or C3-7 cycloalkyl; Ar1 represents phenylene or pyridylene which can be optionally substituted; V represents C1-4 alkyl, C3-7 cycloalkyl, aryl, aryl-(C1-4)alkyl or a 5- or 6-membered aromatic heterocycle; the group X-Y represents C = C or CH-CR3; R3 represents hydrogen, C1-4 alkyl or aryl-(C1-4)alkyl; Z represents among others -CO2R4, -tetrazol-5-yl, -CONHS02R4, -CONR4R5, -CH2NHSO2R4; R4 and R5 independently represent hydrogen, C1-4 alkyl, aryl, aryl-(C1-4)alkyl or perfluoro-(C1-4)alkyl; W represents hydrogen, cyano, C1-4 alkyl, C1-4 haloalkyl, C3-7 cycloalkyl, aryl, aryl-(C1-4)alkyl, C1 -4 alkylsulfonyl, C1 -4 alkylsulfinyl, C1 -4 alkylthio, C1 -4 alkoxy, C1-4 alkylcarbonyl, halogen, hydroxymethyl or C1-4 alkoxymethyl, or W can have any of the meanings disclosed for Z. These compounds are angiotensin II antagonists.

  本发明涉及公式I的新咪唑吡啶衍生物，其中：A、B、C和D中的一个为N，另外三个为CR，其中每个R独立地代表氢、C1-4烷基、COOH或卤素；R1代表C1-4烷基或C3-7环烷基；Ar1代表苯基或吡啶基，可以选择性地被取代；V代表C1-4烷基、C3-7环烷基、芳基、芳基-(C1-4)烷基或5-或6-成员芳香杂环；X-Y基团代表C = C或CH-CR3；R3代表氢、C1-4烷基或芳基-(C1-4)烷基；Z代表等等的基团之一，如-CO2R4、-四唑-5-基、-CONHSO2R4、-CONR4R5、-CH2NHSO2R4；R4和R5独立地代表氢、C1-4烷基、芳基、芳基-(C1-4)烷基或全氟-(C1-4)烷基；W代表氢、氰基、C1-4烷基、C1-4卤代烷基、C3-7环烷基、芳基、芳基-(C1-4)烷基、C1-4烷基磺酰基、C1-4烷基亚砜基、C1-4烷基硫基、C1-4烷氧基、C1-4烷基羰基、卤素、羟甲基或C1-4烷氧甲基，或W可以具有Z所披露的任何含义。这些化合物是血管紧张素II拮抗剂。
• US5554624A
  申请人：——

  公开号：US5554624A

  公开（公告）日：1996-09-10
• Imidazopyridine derivatives as angiotensin II antagonists
  申请人：J. Uriach & Cia.

  公开号：US05554624A1

  公开（公告）日：1996-09-10

  The present invention relates to new imidazopyridine derivatives of formula I ##STR1## wherein: one of A, B, C and D is N and the other are CR, wherein each R independently represents hydrogen, C.sub.1-4 alkyl, COOH or halogen; R.sub.1 represents C.sub.1-4 alkyl or C.sub.3-7 cycloalkyl; Ar.sub.1 represents phenyl or pyridyl which can be optionally substituted; V represents C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl, aryl, aryl-(C.sub.1-4)alkyl or a 5- or 6-membered aromatic heterocycle; the group X-Y represents C.dbd.C or CH--CR.sub.3 ; R.sub.3 represents hydrogen, C.sub.1-4 alkyl or aryl-(C.sub.1-4)alkyl; Z represents among others --CO.sub.2 R.sub.4, --tetrazol-5-yl, --CONHSO.sub.2 R.sub.4, --CONR.sub.4 R.sub.5,--CH.sub.2 NHSO.sub.2 R.sub.4 ; R.sub.4 and R.sub.5 independently represent hydrogen, C.sub.1-4 alkyl, aryl, aryl-(C.sub.1-4)alkyl or perfluoro-(C.sub.1-4)alkyl; W represents hydrogen, cyano, C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, C.sub.3-7 cycloalkyl, aryl, aryl-(C.sub.1-4)alkyl, C.sub.1-4 alkylsulfonyl, C.sub.1-4 alkylsulfinyl, C.sub.1-4 alkylthio, C.sub.1-4 alkoxy, C.sub.1-4 alkylcarbonyl, halogen, hydroxymethyl or C.sub.1-4 alkoxymethyl, or W can have any of the meanings disclosed for Z. These compounds are angiotensin II antagonists.

  本发明涉及公式I的新咪唑吡啶衍生物，其中：A、B、C和D中的一个是N，另外三个是CR，其中每个R独立地代表氢、C.sub.1-4烷基、COOH或卤素；R.sub.1代表C.sub.1-4烷基或C.sub.3-7环烷基；Ar.sub.1代表苯基或吡啶基，可以选择性地被取代；V代表C.sub.1-4烷基、C.sub.3-7环烷基、芳基、芳基-(C.sub.1-4)烷基或5-或6-成员芳香杂环；X-Y代表C.dbd.C或CH--CR.sub.3；R.sub.3代表氢、C.sub.1-4烷基或芳基-(C.sub.1-4)烷基；Z代表--CO.sub.2R.sub.4、--四唑-5-基、--CONHSO.sub.2R.sub.4、--CONR.sub.4R.sub.5、--CH.sub.2NHSO.sub.2R.sub.4等；R.sub.4和R.sub.5独立地代表氢、C.sub.1-4烷基、芳基、芳基-(C.sub.1-4)烷基或全氟-(C.sub.1-4)烷基；W代表氢、氰基、C.sub.1-4烷基、C.sub.1-4卤代烷基、C.sub.3-7环烷基、芳基、芳基-(C.sub.1-4)烷基、C.sub.1-4烷基磺酰基、C.sub.1-4烷基亚砜基、C.sub.1-4烷基硫基、C.sub.1-4烷氧基、C.sub.1-4烷基羰基、卤素、羟甲基或C.sub.1-4烷氧甲基，或W可以具有Z所披露的任何含义。这些化合物是血管紧张素II拮抗剂。