2-(2'-methylpropyl)-4,6-dimethoxy-1,3,5-triazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 2-(2'-methylpropyl)-4,6-dimethoxy-1,3,5-triazine
• 英文别名: 2,4-Dimethoxy-6-(2-methylpropyl)-1,3,5-triazine；2,4-dimethoxy-6-(2-methylpropyl)-1,3,5-triazine
• 化学式: C₉H₁₅N₃O₂
• 分子量: 197.237
• InChiKey: GJIJCFZYMSFYCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氯-4,6-二甲氧基-1,3,5-三嗪 、 三异丁基铝 在 bis-triphenylphosphine-palladium(II) chloride 作用下， 以 乙醚 为溶剂， 反应 2.0h， 以70%的产率得到2-(2'-methylpropyl)-4,6-dimethoxy-1,3,5-triazine
  参考文献：
  名称：

  Organometallic alkylation of 2-chloro-4,6-dimethoxy-1,3,5-triazine: a study

  摘要：

  The reactivity of 2-chloro-4,6-dimethoxy-1,3,5-triazine (1) has been investigated in Pd- or Ni-catalyzed cross-coupling processes with organostannanes, Grignard reagents, organoalanes and organozinc halides. All organometallic reagents considered form new C-C bonds on the heteroaromatic ring and afford the corresponding 2-alkyl-4,6-dimethoxy-1,3,5-triazines in moderate to very good yields. The collected data allows the choice of the alkylating agent as well as the experimental conditions depending on the residue to transfer. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.02.085

文献信息

• Organometallic alkylation of 2-chloro-4,6-dimethoxy-1,3,5-triazine: a study
  作者：Simona Samaritani、Giovanni Signore、Corrado Malanga、Rita Menicagli

  DOI：10.1016/j.tet.2005.02.085

  日期：2005.5

  The reactivity of 2-chloro-4,6-dimethoxy-1,3,5-triazine (1) has been investigated in Pd- or Ni-catalyzed cross-coupling processes with organostannanes, Grignard reagents, organoalanes and organozinc halides. All organometallic reagents considered form new C-C bonds on the heteroaromatic ring and afford the corresponding 2-alkyl-4,6-dimethoxy-1,3,5-triazines in moderate to very good yields. The collected data allows the choice of the alkylating agent as well as the experimental conditions depending on the residue to transfer. (c) 2005 Elsevier Ltd. All rights reserved.