[1-(3,3-Dimethyl-2-oxopentanoyl)pyrrolidin-2-yl]-N-(thien-2-ylcarbonylamino)-formamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: [1-(3,3-Dimethyl-2-oxopentanoyl)pyrrolidin-2-yl]-N-(thien-2-ylcarbonylamino)-formamide
• 英文别名: [1-(3,3-Dimethyl-2-oxopentanoyl)pyrrolidin-2-yl]-N-(2-thienylcarbonylamino)-formamide；N-[1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidin-2-yl]-N-(thiophene-2-carbonylamino)formamide
• 化学式: C₁₇H₂₃N₃O₄S
• 分子量: 365.453
• InChiKey: DERWVOTYNXIOAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
  申请人：Guilford Pharmaceuticals

  公开号：US20030186961A1

  公开（公告）日：2003-10-02

  This invention relates to novel N-heterocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, for treating alopecia and promoting hair growth, for treating vision disorders and/or improving vision, and for treating memory impairment and/or enhancing memory performance by administering such compounds.

  本发明涉及新型 N-杂环羧酸和羧酸异构体、其制备方法以及用于治疗神经系统疾病（包括物理损伤神经和神经退行性疾病）、治疗脱发和促进毛发生长、治疗视力障碍和/或改善视力，以及通过施用此类化合物治疗记忆损伤和/或增强记忆能力的用途。
• CARBOXYLIC ACIDS AND CARBOXYLIC ACID ISOSTERES OF N-HETEROCYCLIC COMPOUNDS
  申请人：GPI NIL Holdings, Inc.

  公开号：EP1135370A2

  公开（公告）日：2001-09-26
• US6331537B1
  申请人：——

  公开号：US6331537B1

  公开（公告）日：2001-12-18
• US7153883B2
  申请人：——

  公开号：US7153883B2

  公开（公告）日：2006-12-26
• [EN] CARBOXYLIC ACIDS AND CARBOXYLIC ACID ISOSTERES OF N-HETEROCYCLIC COMPOUNDS<br/>[FR] ACIDES CARBOXYLIQUES ET ISOSTERES D'ACIDES CARBOXYLIQUES DE COMPOSES N-HETEROCYCLIQUES
  申请人：GUILFORD PHARM INC

  公开号：WO2000032588A2

  公开（公告）日：2000-06-08

  This invention relates to novel N-heterocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, for treating alopecia and promoting hair growth, for treating vision disorders and/or improving vision, and for treating memory impairment and/or enhancing memory performance by administering such compounds.