ethyl vinyl(chloro<(2)H2>methyl)phosphinate

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦酸及其衍生物
• 英文名称: ethyl vinyl(chloro<(2)H2>methyl)phosphinate
• 英文别名: ethyl vinyl[chloro((2)H2)methyl]phosphinate；1-[[Chloro(dideuterio)methyl]-ethenylphosphoryl]oxyethane
• 化学式: C₅H₁₀ClO₂P
• 分子量: 170.544
• InChiKey: NHPGDBDRXZGKIE-BFWBPSQCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ethyl vinyl(chloro<(2)H2>methyl)phosphinate 在 三氯氧磷 作用下， 以61%的产率得到vinyl(chloro<(2)H2>methyl)phosphinic chloride
  参考文献：
  名称：

  Preparation of alkyl- and aryl-amino[²H₂]methylphosphinic acids

  摘要：

  Diethyl chloro[H-2(2)]methylphosphonate upon successive treatment with POCl3 and Grignard reagents (RMgX) gave alkyl(chloro[H-2(2)] methyl)pho sphinates. Phenyl(chloro[H-2(2)]methyl)phosphinate was prepared by deuteriolysis of the alpha-silylated alpha-phosphonylated carbanion 11 with D2O. After conversion into trifluoroethyl phosphinic esters, the alkyl- and phenyl-(chloro[H-2(2)]methyl)phosphinates were converted into azides and then reduced and hydrogenated into alkyl- and phenyl-(amino[H-2(2)]lmethyl)phosphinic acids.

  DOI：

  10.1039/p19950002045
• 作为产物：
  描述：

  乙烯基氯化镁 、 ethyl chloro(chloro<(2)H2>methyl)phosphonate 以 四氢呋喃 、 乙醚 为溶剂， 以76%的产率得到ethyl vinyl(chloro<(2)H2>methyl)phosphinate
  参考文献：
  名称：

  Preparation of alkyl- and aryl-amino[²H₂]methylphosphinic acids

  摘要：

  Diethyl chloro[H-2(2)]methylphosphonate upon successive treatment with POCl3 and Grignard reagents (RMgX) gave alkyl(chloro[H-2(2)] methyl)pho sphinates. Phenyl(chloro[H-2(2)]methyl)phosphinate was prepared by deuteriolysis of the alpha-silylated alpha-phosphonylated carbanion 11 with D2O. After conversion into trifluoroethyl phosphinic esters, the alkyl- and phenyl-(chloro[H-2(2)]methyl)phosphinates were converted into azides and then reduced and hydrogenated into alkyl- and phenyl-(amino[H-2(2)]lmethyl)phosphinic acids.

  DOI：

  10.1039/p19950002045

文献信息

• Preparation of alkyl- and aryl-amino[²H₂]methylphosphinic acids
  作者：Sylvie Berté-Verrando、François Nief、Carl Patois、Philippe Savignac

  DOI：10.1039/p19950002045

  日期：——

  Diethyl chloro[H-2(2)]methylphosphonate upon successive treatment with POCl3 and Grignard reagents (RMgX) gave alkyl(chloro[H-2(2)] methyl)pho sphinates. Phenyl(chloro[H-2(2)]methyl)phosphinate was prepared by deuteriolysis of the alpha-silylated alpha-phosphonylated carbanion 11 with D2O. After conversion into trifluoroethyl phosphinic esters, the alkyl- and phenyl-(chloro[H-2(2)]methyl)phosphinates were converted into azides and then reduced and hydrogenated into alkyl- and phenyl-(amino[H-2(2)]lmethyl)phosphinic acids.