tert-Butyl (3S,5S)-3,5-dihydroxypiperidine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-Butyl (3S,5S)-3,5-dihydroxypiperidine-1-carboxylate
• 英文别名: tert-butyl (3S,5S)-3,5-dihydroxypiperidine-1-carboxylate
• 化学式: C₁₀H₁₉NO₄
• 分子量: 217.26
• InChiKey: KSUUHOYXJWSXIA-YUMQZZPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  70
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] TRISUBSTITUTED PYRAZOLO [1,5-A] PYRIMIDINE COMPOUNDS AS CDK7 INHIBITORS<br/>[FR] COMPOSÉS PYRAZOLO[1,5-A] PYRIMIDINE TRISUBSTITUÉS UTILISÉS EN TANT QU'INHIBITEURS DE CDK7
  申请人：TRANSLATIONAL GENOMICS RES INST

  公开号：WO2020186196A1

  公开（公告）日：2020-09-17

  Compounds having activity as cancer agents are provided. The compounds have the following structure (I) or a pharmaceutically acceptable salts, stereoisomers, tautomers, thereof, wherein R1, R2, R3 and L are as defined herein. This disclosure provides methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds, and methods for treating a CDK7-dependent disease (e.g., cancer).

  提供具有作为抗癌剂活性的化合物。这些化合物具有以下结构（I）或其药用可接受的盐、立体异构体、互变异构体，其中R1、R2、R3和L如本文所定义。本公开提供了与制备和使用这些化合物相关的方法，包括含有这些化合物的药物组合物，以及治疗CDK7依赖性疾病（例如癌症）的方法。
• TRISUBSTITUTED PYRAZOLO [1,5-A] PYRIMIDINE COMPOUNDS AS CDK7 INHIBITORS
  申请人：THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE

  公开号：US20220144841A1

  公开（公告）日：2022-05-12

  Compounds having activity as cancer agents are provided. The compounds have the following structure (I) or a pharmaceutically acceptable salts, stereoisomers, tautomers, thereof, wherein R 1 , R 2 , R 3 and L are as defined herein. This disclosure provides methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds, and methods for treating a CDK7-dependent disease (e.g., cancer).