tert-butyl (1S,4R)-1-(aminomethyl)-2-azabicyclo[2.2.1]heptane-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl (1S,4R)-1-(aminomethyl)-2-azabicyclo[2.2.1]heptane-2-carboxylate
• 化学式: C₁₂H₂₂N₂O₂
• 分子量: 226.32
• InChiKey: ILROOPKXIQCYMQ-SKDRFNHKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HIV INFECTIONS<br/>[FR] COMPOSÉS DE CARBAMOYLPYRIDONE POLYCYCLIQUE ET LEUR UTILISATION POUR LE TRAITEMENT DES INFECTIONS À VIH
  申请人：GILEAD SCIENCES INC

  公开号：WO2015006733A1

  公开（公告）日：2015-01-15

  Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  本发明涉及用于治疗人类免疫缺陷病毒（HIV）感染的化合物。这些化合物具有以下化学式（I）：（I），包括立体异构体和其药用可接受盐，其中L、R1、R5、W、X、Y1、Y2和Z如本文所定义。本发明还涉及与制备和使用此类化合物相关的方法，以及包含此类化合物的药物组合物。
• Substituted dipyrido[1,2-a:1′,2′-d]pyrazines for treating viral infections
  申请人：Gilead Sciences, Inc.

  公开号：US10456395B2

  公开（公告）日：2019-10-29

  Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  本研究公开了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。这些化合物具有下式 (I)： 其中 L、R1、R5、W、X、Y1、Y2 和 Z 如本文所定义。此外，还公开了与制备和使用此类化合物相关的方法，以及包含此类化合物的药物组合物。
• Substituted pyrido[1,2-a]pyrrolo[1,2-d]pyrazines for treating viral infections
  申请人：Gilead Sciences, Inc.

  公开号：US11213523B2

  公开（公告）日：2022-01-04

  Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  本研究公开了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。这些化合物具有下式 (I)： 其中 L、R1、R5、W、X、Y1、Y2 和 Z 如本文所定义。此外，还公开了与制备和使用此类化合物相关的方法，以及包含此类化合物的药物组合物。
• POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HIV INFECTIONS
  申请人：Gilead Sciences, Inc.

  公开号：EP3019499B1

  公开（公告）日：2017-09-06
• POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
  申请人：Gilead Sciences, Inc.

  公开号：US20170128444A1

  公开（公告）日：2017-05-11

  Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R 5 , W, X, Y 1 , Y 2 , and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.