(8R)-5-azaspiro[2.5]octan-8-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (8R)-5-azaspiro[2.5]octan-8-ol
• 化学式: C₇H₁₃NO
• 分子量: 127.18
• InChiKey: XFVIPNSXLIWOIR-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] STEREOSPECIFIC PROCESS FOR 3-HETEROCYCLYLCYCLOALIPHATIC-1,2-DIOLS<br/>[FR] PROCÉDÉ STÉRÉOSPÉCIFIQUE POUR DIOLS 3-HETEROCYCLYLCYCLOALIPHATIQUES-1,2
  申请人：ICAHN SCHOOL OF MEDECINE AT MOUNT SINAI

  公开号：WO2017024229A1

  公开（公告）日：2017-02-09

  A process for the stereoselective synthesis of chiral 3-heterocyclyl-1,2-dihydroxy cyclohexanes is disclosed. The process involves reacting a tricyclic nitrogenous heterocycle with an allyl carbonate in the presence of a chiral palladium catalyst followed by oxidation of the olefinic bond to provide 3-heterocyclyl-1,2-dihydroxy cyclohexanes, cyclopentanes and corresponding alicyclic heterocycles. Also disclosed are methods for converting the heterocyclyl-1,2-dihydroxy cyclohexanes to 2-amino-6-(heteroaryl)cyclohexanols (and related cyclic compounds).