双[2-(三甲基硅氧基)乙基]醚 | 16654-74-3

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 中文名称: 双[2-(三甲基硅氧基)乙基]醚
• 英文名称: 1-{2-[2-(1,1-dimethyl-1-silaethoxy)ethoxy]ethoxy}-1,1-dimethyl-1-silaethane
• 英文别名: 2,2,10,10-tetramethyl-3,6,9-trioxa-2,10-disilaundecane；Bis[2-(trimethylsilyloxy)ethyl] Ether；trimethyl-[2-(2-trimethylsilyloxyethoxy)ethoxy]silane
• CAS: 16654-74-3
• 化学式: C₁₀H₂₆O₃Si₂
• 分子量: 250.486
• InChiKey: VZCNNAQIFXLAEZ-UHFFFAOYSA-N

物化性质

• 沸点：
  87°C/5mmHg(lit.)
• 密度：
  0.8838 g/cm3
• 保留指数：
  1227.1;1238.7

计算性质

• 辛醇/水分配系数(LogP)：
  2.71
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2931900090
• 储存条件：
  室温且干燥环境中保存。

SDS

Bis[2-(trimethylsilyloxy)ethyl] Ether Revision number: 1
SAFETY DATA SHEET

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Section 1. BASE INFORMATION
Product name: Bis[2-(trimethylsilyloxy)ethyl] Ether

Revision number: 1

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Section 2. HAZARDS IDENTIFICATION
Classification of the GHS
PHYSICAL HAZARDS
Flammable liquids Category 4
Not classified
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS Not classified
GHS label elements
Pictograms or hazard symbols None
Warning
Signal word
Hazard statement Combustible liquid
Precautionary statements
[Prevention] Keep away from flames and hot surfaces.
Wear protective gloves and eye/face protection.
[Storage] Store in a well-ventilated place. Keep cool.
Dispose of contents/container through a waste management company authorized by
[Disposal]
the local government

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Component(s): Bis[2-(trimethylsilyloxy)ethyl] Ether
Percent: >98.0%(GC)
16654-74-3
CAS Number:
Synonyms: Diethylene Glycol Bis(trimethylsilyl Ether)
Chemical Formula: C10H26O3Si2

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Rinse skin with
water/shower. If skin irritation or rash occurs: Get medical advice/attention.
Rinse cautiously with water for several minutes. Remove contact lenses, if present
Eye contact:
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
Protection of first-aiders: A rescuer should wear personal protective equipment, such as rubber gloves and air-
tight goggles.
Bis[2-(trimethylsilyloxy)ethyl] Ether

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, carbon dioxide.
media:
Extinguishing media not to Water (It may scatter and spread fire.)
be used:
Specific hazards: Take care as it may decompose upon combustion or in high temperatures to
generate poisonous fume.
Specific methods: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Use personal protective equipment. Keep people away from and upwind of spill/leak.
Personal precautions,
protective equipment and Ensure adequate ventilation. Entry to non-involved personnel should be controlled
emergency procedures: around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in a suitable absorbent (e.g. rag, dry sand, earth, saw-dust).
containment and cleaning In case of large amount of spillage, contain a spill by bunding. Adhered or collected
up: material should be promptly disposed of, in accordance with appropriate laws and
regulations.
Prevention of secondary Remove all sources of ignition. Fire-extinguishing devices should be prepared in
hazards: case of a fire. Use spark-proof tools and explosion-proof equipment.

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Section 7. HANDLING AND STORAGE
Handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapor or mist. Keep away from flames and hot surfaces. Take
measures to prevent the build up of electrostatic charge. Use explosion-proof
equipment. Wash hands and face thoroughly after handling.
Use a closed system, ventilation.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Storage
Storage conditions: Keep container tightly closed. Store in a cool, dark and well-ventilated place.
Store away from incompatible materials such as oxidizing agents.
Packaging material: Law is followed.

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Install a closed system or local exhaust as possible so that workers should not be
Engineering controls:
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Vapor respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Eye protection: Safety glasses. A face-shield, if the situation requires.
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Liquid
Form: clear
Color: Colorless - Almost colorless
Odor: No data available
pH: No data available
Melting point/freezing point:No data available
87 °C/0.7kPa
Boiling Point/Range:
Flash Point: No data available
Bis[2-(trimethylsilyloxy)ethyl] Ether

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Explosive limits
No data available
Lower:
Upper: No data available
0.89
Density:
Solubility: No data available

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Section 10. STABILITY AND REACTIVITY
Stability: Stable under proper conditions.
Reactivity: No special reactivity has been reported.
Incompartible materials: oxidizing agents
Hazardous Decomposition Carbon monoxide, Carbon dioxide, Silicon oxides
Products:

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Section 11. TOXICOLOGICAL INFORMATION
No data available
Acute Toxicity:
Skin corrosion/irritation: No data available
No data available
Serious eye
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
No data available
IARC =
NTP = No data available
No data available
Reproductive toxicity:

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
Crustacea: No data available
Algae: No data available
Persistence / degradability: No data available
Bioaccumulative No data available
potential(BCF):
Mobillity in soil
log Pow: No data available
Soil adsorption (Koc): No data available
Henry's Law No data available
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when
disposing of the substance.

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Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
UN-No: Not Listed

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26,
2002): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were
prescribed.
Bis[2-(trimethylsilyloxy)ethyl] Ether

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  双[2-(三甲基硅氧基)乙基]醚 在 silicon tetrafluoride 作用下， 以 正己烷 为溶剂， 反应 8.0h， 以47%的产率得到1,1-difluoro-2,5,8-trioxasilocane
  参考文献：
  名称：

  New heterosilocanes, 1,1-difluoroand 1-phenyl-1-fluoro-2,8-dioxa-5-chalcogenosilocanes

  摘要：

  The earlier unknown Si-fluorinated 2,8-dioxa-5-chalcogenosilocanes RFSi(OCH(2)CH(2))(2)Y (R = Ph, F; Y = O, S) were synthesized. According to calculations, there is a weak transannular coordinate interaction Y -> Si (Y = O, S), which is much weaker than that in the isostructural quasisilatranes (Y = N). At low temperatures, 1,1-difluoro-2,5,8-trioxasilocane forms a dimer, in which two molecules of the monomer are linked by four fluorine bridges Si-F -> Si located in pairs in the two orthogonal planes SiF(2)Si.

  DOI：

  10.1134/s1070363210070108
• 作为产物：
  描述：

  六甲基二硅氮烷 以70%的产率得到
  参考文献：
  名称：

  KALCHENKO, V. I;ATAMAS, L. I;SERGUCHEV, YU. A.;MARKOVSKIJ, L. N., ZH. OBSHCH. XIMII, 1984, 54, N 8, 1754-1764

  摘要：

  DOI：

文献信息

• Co2(CO)8-Catalyzed Reactions of Acetals or Lactones with Hydrosilanes and Carbon Monoxide. A New Access to the Preparation of 1,2-Diol Derivatives through Siloxymethylation
  作者：Naoto Chatani、Satoru Fujii、Yoichi Kido、Yasuhide Nakayama、Yasuteru Kajikawa、Hideo Tokuhisa、Yoshiya Fukumoto、Shinji Murai

  DOI：10.1246/bcsj.20200240

  日期：2021.1.15

  The Co2(CO)8-catalyzed reaction of acetals with hydrosilanes and CO under mild reaction conditions (an ambient temperature under an ambient CO pressure), leading to the production of vicinal diols ...

  Co2(CO)8 催化缩醛与氢硅烷和 CO 在温和反应条件（环境温度和环境 CO 压力）下反应，生成邻二醇...
• Polyhalogenated heterocyclic compounds
  作者：Richard D. Chambers、Ali Khalil、Christopher B. Murray、Graham Sandford、Andrei S. Batsanov、Judith A.K. Howard

  DOI：10.1016/j.jfluchem.2005.01.018

  日期：2005.7

  Model studies show that displacement of fluorine, rather than chlorine, occurs upon reaction of 3,5-dichloro-2,4,6-trifluoropyridine with sodium methoxide and phenoxide. Subsequent hydro-dechlorination can be achieved by reaction with lithium aluminium hydride whereas reaction of sodium in iso-propanol leads to formation of the tri-iso-propoxy pyridine derivative, via nucleophilic substitution of the

  模型研究表明，当3,5-二氯-2,4,6-三氟吡啶与甲醇钠和酚盐反应时，会发生氟而不是氯的置换。随后的加氢脱氯化氢可通过与氢化铝锂反应来实现，而钠在异丙醇中的反应则是通过甲氧基的亲核取代而不是脱氯产物形成三异丙氧基吡啶衍生物。大环化合物可以通过适当的双官能氧亲核试剂与3,5-二氯-2,4,6-三氟吡啶的反应合成，其中一种通过X射线晶体学表征。
• Polyhalogenated heterocyclic compounds. Macrocycles from perfluoro-4-isopropylpyridinePart 50. For part 49 see ref. 1.
  作者：Richard D. Chambers、Philip R. Hoskin、Alan R. Kenwright、Ali Khalil、Paul Richmond、Graham Sandford、Dmitrii S. Yufit、Judith A. K. Howard

  DOI：10.1039/b303443g

  日期：——

  Perfluoro-4-isopropylpyridine was used as a building block for the two-step synthesis of a variety of macrocyclic systems bearing pyridine sub-units which were characterised by X-ray crystallography. Electrospray mass spectrometry revealed that complexation of either cations and, unusually, anions is possible depending on the structure of the macrocycle.

  全氟-4-异丙基吡啶被用作两步合成多种含吡啶亚基的大环体系的构建模块，这些大环体系通过X射线晶体学进行了表征。电喷雾质谱分析表明，根据大环的结构，阳离子和阴离子（罕见）都有可能发生络合反应。
• Design, synthesis, and biological evaluation of multiple F-18 S1PR1 radiotracers in rodent and nonhuman primate
  作者：Lin Qiu、Hao Jiang、Charles Zhou、Vijai Kumar Reddy Tangadanchu、Jinzhi Wang、Tianyu Huang、Robert J. Gropler、Joel S. Perlmutter、Tammie L. S. Benzinger、Zhude Tu

  DOI：10.1039/d4ob00712c

  日期：——

  of [18F]7c and [18F]7d in rat plasma and brain samples found that [18F]7c has a more favorable metabolic profile than [18F]7d. However, the trend of increased brain uptake precludes [18F]7c as a suitable PET radiotracer for imaging S1PR1 in the brain. Further structural optmization is warranted to identify a highly S1PR1-specific radiotracer with rapid brain uptake kinetics.

  在此，我们报告了 28 种新型含氟化合物的设计和合成，作为潜在的 F-18 放射性示踪剂，用于 1-磷酸鞘氨醇受体 1 (S1PR1) 的 CNS 成像，并测定了它们对 S1PR1 相对于其他 S1PR 的体外结合效力和选择性亚型。九种有效且选择性的化合物， 7c&d 、 9a&c 、 12b 、 15b和18a–c ，对 S1PR1 的 IC 50值范围为 0.6–12.3 nM，并且与 S1PR2、3、4 和 5 的结合较弱，进一步进行18 F 放射性标记产生[ 18 F] 7c&d 、[ 18 F] 9a&c 、[ 18 F] 12b 、[ 18 F] 15b和[ 18 F] 18a–c 。研究了[ 18 F] 7c&d和[ 18 F] 9a&c放射合成的多步F-18 放射化学程序，合成了假定的中间体并通过分析型HPLC 进行了验证。 然后，我们对八种放射性示踪剂进行了非人灵长类动物
• Lakouraj; Akbari, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, vol. 42, # 5, p. 1165 - 1167
  作者：Lakouraj、Akbari

  DOI：——

  日期：——