1-[3-[4-[(4-Fluorophenyl)methyl]piperidin-1-yl]-2-hydroxypropyl]-3-(3-methoxyphenyl)urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-[3-[4-[(4-Fluorophenyl)methyl]piperidin-1-yl]-2-hydroxypropyl]-3-(3-methoxyphenyl)urea
• 化学式: C₂₃H₃₀FN₃O₃
• 分子量: 415.5
• InChiKey: UJPWHPZFNCTMHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  73.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
  申请人：——

  公开号：US20040002515A1

  公开（公告）日：2004-01-01

  The present application describes modulators of CCR3 of formula (I): 1 or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.

  本申请描述了CCR3调节剂的公式(I)1或其药学上可接受的盐形式，适用于预防哮喘和其他过敏性疾病。
• [EN] OPTICAL MEMBERS, AND PROCESSES, COMPOSITIONS AND POLYMERS FOR PREPARING THEM<br/>[FR] ELEMENTS OPTIQUES ET PROCEDES, COMPOSITIONS ET POLYMERES UTILISES DANS LA PREPARATION DE CES DERNIERS
  申请人：FUJI PHOTO FILM CO LTD

  公开号：WO2004022614A2

  公开（公告）日：2004-03-18

  Novel optical members formed of a polymer comprising a repeating unit derived from a polymerizable monomer (A) which is a methacrylate derivative having a branched C3-8 alkyl group or a repeating unit derived from a polymerizable monomer (3) which is a (meth)acrylate derivative having a C7-20 alicyclic hydrocarbon group are disclosed. Novel processes for preparing an optical member comprising polymerization of a composition comprising the monomer (A) or the monomer (3) are also disclosed.

  本发明涉及一种新型光学元件，该元件由包含源自可聚合单体(A)的重复单元的聚合物形成，其中单体(A)是一种具有支化C3-8烷基的甲基丙烯酸酯衍生物，或者源自可聚合单体(3)的重复单元，其中单体(3)是具有C7-20脂环族烃基的(甲基)丙烯酸酯衍生物。还披露了通过聚合包含单体(A)或单体(3)的组合物来制备光学元件的新型工艺。
• [EN] OPTICAL MEMBERS AND COMPOSITIONS FOR PRODUCING THEM<br/>[FR] ELEMENTS OPTIQUES ET COMPOSITIONS POUR PRODUIRE CEUX-CI
  申请人：FUJI PHOTO FILM CO LTD

  公开号：WO2004046203A2

  公开（公告）日：2004-06-03

  It is disclosed a polymerizable composition for producing an optical member for 850 nm wavelength comprising: a polymerizable monomer composition and a compound, having a different refractive index from that of the polymerizable monomer composition, whose structure has a benzene ring substituted by a substituent having a Hammett value of not greater than 0.04 or by plural substituents having an average value of Hammett values thereof of not greater than 0.04. It is also disclosed a polymerizable composition for producing an optical member comprising a polymerizable monomer composition comprising at least one selected from the group consisting of C7-20 alicyclic (meth)acrylates and a compound, having a different refractive index from that of the polymerizable monomer composition and having a solubility parameter of not greater than 10.9, whose structure has a benzene ring substituted by the substituent or the substituents defined above.

  本发明公开了一种用于生产850 nm波长光学元件的可聚合组合物，包含：可聚合单体组合物和具有与所述可聚合单体组合物不同折射率的化合物，其结构中具有被取代基(所述取代基的Hammett值不大于0.04)或多个取代基(所述多个取代基的平均Hammett值不大于0.04)取代的苯环。 本发明还公开了一种用于生产光学元件的可聚合组合物，包含：包含至少一种选自C7-20环状（甲基）丙烯酸酯的可聚合单体组合物，以及具有与所述可聚合单体组合物不同折射率、其溶解度参数不大于10.9的化合物，其结构中具有所述取代基或多个取代基取代的苯环。
• EP1158980A4
  申请人：——

  公开号：EP1158980A4

  公开（公告）日：2002-04-03
• N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
  申请人：Bristol-Myers Squibb Pharma Company

  公开号：EP1158980B1

  公开（公告）日：2005-08-24