(3S)-9-benzyl-1-butyl-3-(cyclohexylmethyl)-11-methyl-1,4,9-triazaspiro[5.5]undecane-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3S)-9-benzyl-1-butyl-3-(cyclohexylmethyl)-11-methyl-1,4,9-triazaspiro[5.5]undecane-2,5-dione
• 化学式: C₂₇H₄₁N₃O₂
• 分子量: 439.6
• InChiKey: BCHKUXGBPFYWII-BMMPOPSUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  52.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Nitrogen-containing heterocyclic compounds and use thereof
  申请人：Nishizawa Rena

  公开号：US20070155713A1

  公开（公告）日：2007-07-05

  A pharmaceutical composition comprising, as an active ingredient, the compounds represented by formula (I) (wherein all of the symbols have the same meanings as defined in specification.), salts thereof, solvates thereof, or prodrugs thereof. The compounds represented by formula (I) are used for prevention and/or treatment of various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, chronic rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis and the like), immunologic diseases (treatment of autoimmune diseases, transplant rejection, immunosuppression, psoriasis, multiple sclerosis and the like), human immunodeficiency virus infection (acquired immunodeficiency syndrome and the like), allergic diseases (atopic dermatitis, nettle rash, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis and the like), suppression of ischemia-reperfusion injury, acute respiratory distress syndrome, shock accompanied by bacterial infection, diabetes mellitus, or metastasis and the like.