6-(4-Benzyl-piperidine-1-carbonyl)-2,3,4,9-tetrahydro-β-carbolin-1-one | 300715-90-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 6-(4-Benzyl-piperidine-1-carbonyl)-2,3,4,9-tetrahydro-β-carbolin-1-one
• 英文别名: 6-(4-Benzylpiperidine-1-carbonyl)-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-one
• CAS: 300715-90-6
• 化学式: C₂₄H₂₅N₃O₂
• 分子量: 387.481
• InChiKey: KPBXDSTUIPZKEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  65.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS<br/>[FR] COMPOSES ET PROCEDES DE TRAITEMENT DE L'INSUFFISANCE CARDIAQUE ET D'AUTRES TROUBLES
  申请人：SCIOS INC

  公开号：WO2000059904A2

  公开（公告）日：2000-10-12

  Compounds of formula (I), (υ) wherein the dotted line represents an optional bond; and the pharmaceutically acceptable salts thereof, wherein X1 is an alkyl bridge optionally containing an O, S, or N heteroatom that forms an aliphatic 5-7 membered ring and is optionally substituted by one or more of halo, OR, SR, NR¿2?, RCO, COOR, CONR2, OOCR, or NROCR where R is H or alkyl (1-6C), or by one or more CN or =O, or by one or more aliphatic or aromatic 5-or 6-membered rings optionally containing 1-2 heteroatoms; R?1¿ is (a). These compounds are selective inhibitors of p38α kinase.