1-[5-(2-Thienoyl)-1-methyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)ethanone | 388115-28-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 1-[5-(2-Thienoyl)-1-methyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)ethanone
• 英文别名: 1-[1-Methyl-5-(thiophene-2-carbonyl)pyrrol-3-yl]-2-piperidin-1-ylethanone
• CAS: 388115-28-4
• 化学式: C₁₇H₂₀N₂O₂S
• 分子量: 316.424
• InChiKey: BQZUSJZAWRYFBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  70.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Useful aroyl aminoacyl pyrrole compounds
  申请人：——

  公开号：US20020019436A1

  公开（公告）日：2002-02-14

  This invention is directed to aroyl aminoacyl pyrroles pharmaceutically useful as agents and modulators for the treatment of central nervous system disorders and a method for the treatment of central nervous system disorders including, but not limited to, use of the compounds of the present invention as anticonvulsant agents and modulators, antiepileptic agents and modulators, neuroprotective agents and modulators, muscle relaxant agents and modulators and as agents and modulators for the treatment of neuropathic pain.

  本发明涉及具有药用价值的芳基氨基酰基吡咯类化合物，用作治疗中枢神经系统疾病的药物和调节剂，以及治疗中枢神经系统疾病的方法，其中包括但不限于使用本发明化合物作为抗癫痫剂和调节剂、抗癫痫剂和调节剂、神经保护剂和调节剂、肌肉松弛剂和调节剂以及治疗神经病性疼痛的药物和调节剂。
• US6573267B2
  申请人：——

  公开号：US6573267B2

  公开（公告）日：2003-06-03
• [EN] USEFUL AROYL AMINOACYL PYRROLE COMPOUNDS<br/>[FR] UTILISATION DE COMPOSES PYRROLES AMINOACYL AROYL
  申请人：ORTHO MCNEIL PHARM INC

  公开号：WO2002002521A2

  公开（公告）日：2002-01-10

  This invention is directed to aroyl aminoacyl pyrroles pharmaceutically useful as agents and modulators for the treatment of central nervous system disorders and a method for the treatment of central nervous system disorders including, but not limited to, use of the compounds of the present invention as anticonvulsant agents and modulators, antiepileptic agents and modulators, neuroprotective agents and modulators, muscle relaxant agents and modulators and as agents and modulators for the treatment of neurpathic pain.