(4-amino-10H-thieno[2,3-c][1]benzazepin-7-yl)-[3-(hydroxymethyl)piperidin-1-yl]methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (4-amino-10H-thieno[2,3-c][1]benzazepin-7-yl)-[3-(hydroxymethyl)piperidin-1-yl]methanone
• 化学式: C₁₉H₂₁N₃O₂S
• 分子量: 355.5
• InChiKey: SFZVQDORPWXGTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS<br/>[FR] COMPOSES
  申请人：ASTRAZENECA AB

  公开号：WO2000073312A1

  公开（公告）日：2000-12-07

  There are provided novel compounds of formula (I), wherein R1, R2, A, Q and X are as defined in the specification, and optical isomers, racemates and tautomers thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase.