1-[3-Benzyl-5-[(2-oxopiperidin-1-yl)methyl]phenyl]-3-(4-methylpyridin-2-yl)propane-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-[3-Benzyl-5-[(2-oxopiperidin-1-yl)methyl]phenyl]-3-(4-methylpyridin-2-yl)propane-1,3-dione
• 化学式: C₂₈H₂₈N₂O₃
• 分子量: 440.5
• InChiKey: HTLWNXWORUYJAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  67.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• 1-(Aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
  申请人：——

  公开号：US20030229079A1

  公开（公告）日：2003-12-11

  Certain 1-(aromatic- or heteroaromatic-substituted-3-(heteroaromatic substituted)-1,3-propanediones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

  某些1-(芳香基或杂芳基取代的3-(杂芳基取代)-1,3-丙二酮被描述为HIV整合酶的抑制剂和HIV复制的抑制剂。这些化合物在预防或治疗HIV感染以及治疗艾滋病方面是有用的，无论是作为化合物、药学上可接受的盐、药用组合成分，无论是否与其他抗病毒药物、免疫调节剂、抗生素或疫苗结合使用。还描述了治疗艾滋病的方法以及预防或治疗HIV感染的方法。
• 1-(AROMATIC- OR HETEROAROMATIC-SUBSTITUTED)-3-(HETEROAROMATIC SUBSTITUTED)-1,3-PROPANEDIONES AND USES THEREOF
  申请人：Merck & Co., Inc.

  公开号：EP1196384A1

  公开（公告）日：2002-04-17
• EP1196384A4
  申请人：——

  公开号：EP1196384A4

  公开（公告）日：2002-10-23
• [EN] 1-(AROMATIC- OR HETEROAROMATIC-SUBSTITUTED)-3-(HETEROAROMATIC SUBSTITUTED)-1,3-PROPANEDIONES AND USES THEREOF<br/>[FR] 1,3-PROPANEDIONES-1-(AROMATIQUES OU HETEROAROMATIQUES SUBSTITUTEES)-3-(HETEROAROMATIQUES SUBSTITUEES) ET LEUR UTILISATION
  申请人：MERCK & CO INC

  公开号：WO2001000578A1

  公开（公告）日：2001-01-04

  Certain 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.