(E)-N-[(2S)-1-[4-[(4-chlorophenyl)methyl]piperidin-1-yl]-3-hydroxypropan-2-yl]-3-(5-cyano-2-methoxyphenyl)prop-2-enamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (E)-N-[(2S)-1-[4-[(4-chlorophenyl)methyl]piperidin-1-yl]-3-hydroxypropan-2-yl]-3-(5-cyano-2-methoxyphenyl)prop-2-enamide
• 化学式: C₂₆H₃₀ClN₃O₃
• 分子量: 468.0
• InChiKey: JDIPZQSQWWUHOW-LUAJHVPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  85.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Derivatives of 3-phenyl-n-(2-(4-benzyl)-piperidin-1-yl)-ethyl)-acrylamid with ccr-3-receptor antagonistic activity for use in the treatment of inflammations and allergic conditions
  申请人：——

  公开号：US20040180926A1

  公开（公告）日：2004-09-16

  This invention relates to organic compounds of formula I, 1 in which Ar 1 is unsubstituted phenyl substituted by one or more halogen atoms; Ar 2 is unsubstituted phenyl or phenyl substituted by one or more substituents selected from the group consisting of halogen, cyano and C 1 -C 8 -alkoxy; R 1 is hydrogen or methyl optionally substituted by hydroxy; R 10 is hydrogen or hydroxy; and pharmaceutically acceptable salts thereof. Compositions containing them, methods for their preparation and their use as pharmaceuticals are also described.

  该发明涉及公式I的有机化合物，其中Ar1是未取代的苯基，被一个或多个卤素原子取代；Ar2是未取代的苯基或被一个或多个取代基所取代的苯基，所述取代基选择自卤素、氰基和C1-C8-烷氧基的群体；R1是氢或甲基，可选地被羟基取代；R10是氢或羟基；以及其药学上可接受的盐。还描述了含有它们的组合物、它们的制备方法以及作为药物的用途。
• DERIVATIVES OF 3-PHENYL-N-(2- (4-BENZYL) PIPERIDIN-1-YL)-ETHYL)-ACRYLAMID WITH CCR-3 RECEPTOR ANTAGONISTIC ACTIVITY FOR USE IN THE TREATMENT OF INFLAMMATIONS AND ALLERGIC CONDITIONS
  申请人：Novartis AG

  公开号：EP1401814A1

  公开（公告）日：2004-03-31
• US7259173B2
  申请人：——

  公开号：US7259173B2

  公开（公告）日：2007-08-21
• [EN] DERIVATIVES OF 3-PHENYL-N-(2- (4-BENZYL) PIPERIDIN-1-YL)-ETHYL)-ACRYLAMID WITH CCR-3 RECEPTOR ANTAGONISTIC ACTIVITY FOR USE IN THE TREATMENT OF INFLAMMATIONS AND ALLERGIC CONDITIONS<br/>[FR] DERIVES DE 3-PHENYL-N-(2- (4-BENZYL) PIPERIDIN-1-YL)-ETHYL)-ACRYLAMIDE AVEC UNE ACTIVITE ANTAGONISTE AU RECEPTEUR DE CCR-3, DESTINES A ETRE UTILISES DANS LE TRAITEMENT D'INFLAMMATIONS ET D'ETATS ALLERGIQUES
  申请人：NOVARTIS AG

  公开号：WO2002102775A1

  公开（公告）日：2002-12-27

  This invention relates to organic compounds of formula I, in which Ar1 is unsubstituted phenyl or phenyl substituted by one or more halogen atoms; Ar2 is unsubstituted phenyl or phenyl substituted by one or more substituents selected from halogen, cyano or C¿1?-C8-alkoxy; R?1¿ is hydrogen or methyl optionally substituted by hydroxy; R10 is hydrogen or hydroxy; and pharmaceutically acceptable salts thereof. Compositions containing them, methods for their preparation and their use as pharmaceuticals are also described.