[1-[2-(2-oxo-1H-quinolin-3-yl)-1H-indole-5-carbonyl]piperidin-4-yl]azanium;2,2,2-trifluoroacetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [1-[2-(2-oxo-1H-quinolin-3-yl)-1H-indole-5-carbonyl]piperidin-4-yl]azanium;2,2,2-trifluoroacetate
• 化学式: C25H23F3N4O4
• 分子量: 500.5
• InChiKey: ICSYWBRLGYNHLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.87
• 重原子数：
  36
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Tyrosine kinase inhibitors
  申请人：Fraley E. Mark

  公开号：US20050096344A1

  公开（公告）日：2005-05-05

  The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

  本发明涉及抑制、调节和/或调节酪氨酸激酶信号传导的化合物，包含这些化合物的组合物以及使用它们治疗哺乳动物的酪氨酸激酶依赖性疾病和情况的方法，例如血管生成、癌症、肿瘤生长、动脉硬化、年龄相关性黄斑变性、糖尿病视网膜病变、炎症性疾病等等。
• TYROSINE KINASE INHIBITORS
  申请人：Merck & Co., Inc.

  公开号：EP1226136B1

  公开（公告）日：2004-12-29
• US6306874B1
  申请人：——

  公开号：US6306874B1

  公开（公告）日：2001-10-23
• US6794393B1
  申请人：——

  公开号：US6794393B1

  公开（公告）日：2004-09-21
• [EN] TYROSINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE TYROSINE KINASES
  申请人：MERCK & CO INC

  公开号：WO2001029025A2

  公开（公告）日：2001-04-26

  The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.