Bis[1-[(4-propanoyloxyphenyl)methyl]-1-azoniabicyclo[2.2.2]octan-3-yl] decanedioate;dibromide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Bis[1-[(4-propanoyloxyphenyl)methyl]-1-azoniabicyclo[2.2.2]octan-3-yl] decanedioate;dibromide
• 化学式: C44H62Br2N2O8
• 分子量: 906.8
• InChiKey: QHQCZABFOZKGOX-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  1.45
• 重原子数：
  56
• 可旋转键数：
  23
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• MONO-ACYLOXY ARALKYL NEUROMUSCULAR RELAXANTS
  申请人：Newlaxant, L.L.C.

  公开号：EP1150673A1

  公开（公告）日：2001-11-07
• EP1150673A4
  申请人：——

  公开号：EP1150673A4

  公开（公告）日：2002-04-24
• [EN] MONO-ACYLOXY ARALKYL NEUROMUSCULAR RELAXANTS<br/>[FR] RELAXANTS NEUROMUSCULAIRES MONO-ACYLOXY ARALKYLES
  申请人：NEWLAXANT L L C

  公开号：WO2000044377A1

  公开（公告）日：2000-08-03

  Mono-acyloxy substituted aralkyl and aralkenyl bis-quaternary ammonium derivatives of cyclic alkanol diesters according to general Formula (a) or (b), where R1 and R1' are mono-acyloxy subst ituted aralkyl or aralkenyl; R2 and R2' are alkyl or alkenyl; A is normal or substituted alkanedicarbonyl, alkenedicarbonyl, alkynedicarbonyl, cycloalkanedicarbonyl, cycloalkenedicarbonyl, bicycloalkanedicarbonyl, bicycloalkenedicarbonyl, polycycloalkanedicarbonyl, polycycloalkenedicarbonyl or aromatic dicarbonyl; n is 0, 1, or 2; m is 0, 1, or 2; p is 0, 1, or 2; R3 and R3' are H, CH3, or lower alkyl; R4 and R4' are H, CH3, or lower alkyl; R3 and R4 together can also be -CH=CH-, -(CH2)h-Y-(CH2)k-, or (1), where Y is CH2, O or S, h is 0, 1, 2 or 3, k is 0, 1, 2 or 3; and R3' and R4' together can also be -CH=CH-, -(CH2)h-Y-(CH2)k-, or (1), where Y is CH2, O or S, h is 0, 1, 2 or 3, k is 0, 1, 2 or 3; wherein R1 and R1', R2 and R2', R3 and R3', and R4 and R4' can be the same or different; and X is a pharmaceutically acceptable anion; have advantageous neuromuscular relaxant properties.