N-[4-(1-benzylpiperidin-4-yl)oxyphenyl]-1-phenylmethanesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-[4-(1-benzylpiperidin-4-yl)oxyphenyl]-1-phenylmethanesulfonamide
• 化学式: C₂₅H₂₈N₂O₃S
• 分子量: 436.6
• InChiKey: CFSQEWCPQOZZSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  67
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Phenoxy piperidines for treating diseases such as schizophrenia and depression
  申请人：Holzemann Gunter

  公开号：US20050131021A1

  公开（公告）日：2005-06-16

  Compounds of the formula (1), in which R 1 , R 2 ′, R 2 ″, R 2 ′″, R 3 and n are as defined in claim 1, are effectors of the nicotinic and/or muscarinic acetylcholine receprot and are suitable for the prophylaxis or treatment of schizophrenia, depression, anxiety states, dementia, Alzheimer's disease, Lewy bodies dementia, neurodegenerative diseases, Parkinson's disease, Huntington's disease, Tourette's syndrome, learning and memory impairments, age-related memory impairment, amelioration of withdrawal symptoms in nicotine dependence, strokes or brain damage by toxic compounds.

  式（1）化合物，其中 R 1 , R 2 ′, R 2 ″, R 2 ′″, R 3 和 n 如权利要求 1 中所定义，是烟碱和/或毒蕈碱乙酰胆碱受体的效应物，适用于预防或治疗精神分裂症、抑郁症、焦虑症、痴呆症、阿尔茨海默病、路易体痴呆症、神经退行性疾病、帕金森病、亨廷顿病、抽动秽语综合征、学习和记忆障碍、与年龄有关的记忆损伤、学习和记忆力减退、神经退行性疾病、帕金森病、亨廷顿病、抽动秽语综合征、学习和记忆障碍、与年龄相关的记忆障碍、改善尼古丁依赖的戒断症状、中风或有毒化合物对大脑的损害。
• PHENOXY-PIPERIDINE ZUR BEHANDLUNG VON ERKRANKUNGEN WIE SCHIZOPHRENIE UND DEPRESSION
  申请人：MERCK PATENT GmbH

  公开号：EP1465868A1

  公开（公告）日：2004-10-13
• JP2005514457A
  申请人：——

  公开号：JP2005514457A

  公开（公告）日：2005-05-19
• 統合失調症およびうつ病等の疾患を処置するためのフェノキシピペリジン
  申请人：メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング

  公开号：JP4727925B2

  公开（公告）日：2005-05-19
• PHENOXY-PIPERIDINES FOR THE TREATMENT OF DISEASES SUCH AS SCHIZOPHRENIA AND DEPRESSION
  申请人：HOLZEMANN Gunter

  公开号：US20090247584A1

  公开（公告）日：2009-10-01

  Compounds of the formula (I), in which R 1 , R 2′ , R 2″ , R 2′″ , R 3 and n are as defined in Claim 1 , are effectors of the nicotinic and/or muscarinic acetylcholine receptor and are suitable for the prophylaxis or treatment of schizophrenia, depression, anxiety states, dementia, Alzheimer's disease, Lewy bodies dementia, neurodegenerative diseases, Parkinson's disease, Huntington's disease, Tourette's syndrome, learning and memory impairments, age-related memory impairment, amelioration of withdrawal symptoms in nicotine dependence, strokes or brain damage by toxic compounds.