8-methyl-N-[4-(morpholin-4-ylmethyl)phenyl]-9-oxo-5,6-dihydrothiepino[4,5-f][1,3]benzodioxole-6-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫平类
• 英文名称: 8-methyl-N-[4-(morpholin-4-ylmethyl)phenyl]-9-oxo-5,6-dihydrothiepino[4,5-f][1,3]benzodioxole-6-carboxamide
• 化学式: C₂₄H₂₆N₂O₅S
• 分子量: 454.5
• InChiKey: CKPSFTSMVSCPKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• BENZOTHIEPIN DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1103552A1

  公开（公告）日：2001-05-30

  The invention provides compounds of the formula: wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen atom or an optionally substituted hydrocarbon group; n is an integer of 0 - 3; or salts thereof, which are useful as medicines having an osteogenesis promoting effect and chondrogensis promoting effect. The present invention relates to an amine compound having an excellent effect of inhibiting production and/or secretion of amyloid-b protein, a production and use thereof. Especially, it is effective for preventing and/or treating, for example, neurodegenerative diseases, amyloid angiopathy, neurological disorders caused by cerebrovascular disorders, and so forth.

  本发明提供了如下式的化合物： 其中，环 A 是任选取代的苯环；R1 是任选取代的非芳香杂环基团；R2 和 R3 独立地是氢原子或任选取代的烃基；n 是 0 - 3 的整数；或其盐，可用作具有促进成骨作用和促进软骨作用的药物。 本发明涉及一种在抑制淀粉样蛋白-b 的产生和/或分泌方面具有卓越效果的胺类化合物及其生产和使用方法。特别是，它对预防和/或治疗神经退行性疾病、淀粉样血管病、脑血管疾病引起的神经系统疾病等有效。
• Benzothiepine derivatives, their production and use
  申请人：——

  公开号：US20020128308A1

  公开（公告）日：2002-09-12

  The invention provides compounds of the formula: 1 wherein the ring A is an optionally substituted benzene ring; R 1 is an optionally substituted non-aromatic heterocyclic group; R 2 and R 3 are independently hydrogen atom or an optionally substituted hydrocarbon group; n is an integer of 0-3; or salts thereof, which are useful as medicines having an osteogenesis promoting effect and chondrogensis promoting effect. The present invention relates to an amine compound having an excellent effect of inhibiting production and/or secretion of amyloid-b protein, a production and use thereof. Especially, it is effective for preventing and/or treating, for example, neurodegenerative diseases, amyloid angiopathy, neurological disorders caused by cerebrovascular disorders, and so forth.

  本发明提供了以下式子的化合物： 1 其中环 A 是任选取代的苯环； R 1 是任选取代的非芳香杂环基团； R 2 和 R 3 独立地为氢原子或任选取代的烃基；n 为 0-3 的整数；或其盐，可用作具有促进成骨作用和促进软骨作用的药物。 本发明涉及一种具有良好抑制淀粉样蛋白-b 生成和/或分泌效果的胺类化合物及其生产和使用方法。特别是，它对预防和/或治疗神经退行性疾病、淀粉样血管病、脑血管疾病引起的神经紊乱等有效。
• US6355672B1
  申请人：——

  公开号：US6355672B1

  公开（公告）日：2002-03-12
• US6531604B2
  申请人：——

  公开号：US6531604B2

  公开（公告）日：2003-03-11