5-tert-butyl-3-[3-(1-ethyl-1H-pyrazol-3-yl)-ureido]-thiophene-2-carboxylic acid methyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 5-tert-butyl-3-[3-(1-ethyl-1H-pyrazol-3-yl)-ureido]-thiophene-2-carboxylic acid methyl ester
• 英文别名: methyl 5-tert-butyl-3-(3-(1-ethyl-1H-pyrazol-3-yl)ureido)thiophene-2-carboxylate；methyl 5-tert-butyl-3-[(1-ethylpyrazol-3-yl)carbamoylamino]thiophene-2-carboxylate
• 化学式: C₁₆H₂₂N₄O₃S
• 分子量: 350.442
• InChiKey: OQFZHVJVOXDNJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Raf kinase inhibitors
  申请人：BAYER CORPORATION and ONYX PHARMACEUTICALS West Haven, CT and Richmond, CA, respectively

  公开号：US20010006975A1

  公开（公告）日：2001-07-05

  Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.

  通过使用替代尿素化合物和这些化合物本身，治疗由Raf激酶介导的肿瘤的方法。
• Raf Kinase Inhibitors
  申请人：WOOD Jill E.

  公开号：US20100063088A1

  公开（公告）日：2010-03-11

  Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.

  使用替代尿素类化合物治疗由Raf激酶介导的肿瘤的方法，以及这些化合物本身。
• RAF KINASE INHIBITORS
  申请人：Bayer Pharmaceuticals Corporation

  公开号：EP0986382B1

  公开（公告）日：2008-06-25
• EP0986382A4
  申请人：——

  公开号：EP0986382A4

  公开（公告）日：2001-04-11
• METHODS FOR TREATING A TUMOR USING AN ANTIBODY THAT SPECIFICALLY BINDS GRP94
  申请人：Ferrone Soldano

  公开号：US20120148598A1

  公开（公告）日：2012-06-14

  Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer express a mutated BRAF. Methods are disclosed for treating a subject diagnosed with a tumor that expresses a mutated BRAF. The methods include administering to the subject (1) a therapeutically effective amount of an antibody or antigen binding fragment thereof that specifically binds glucose regulated protein (GRP) 94; and (2) a therapeutically effective amount of a BRAF inhibitor. In some embodiments, the tumor is melanoma. In some embodiments the method includes selecting a subject with primary or secondary resistance to a BRAF inhibitor. In further embodiments, treating the tumor comprises decreasing the metastasis of the tumor. In additional embodiments, the BRAF inhibitor comprises PLX4032 or PLX4720.