(6R)-N,6-dihydroxy-6-[4-(1-methylpiperidin-4-yl)phenyl]hexanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (6R)-N,6-dihydroxy-6-[4-(1-methylpiperidin-4-yl)phenyl]hexanamide
• 化学式: C₁₈H₂₈N₂O₃
• 分子量: 320.4
• InChiKey: PLPPKATVJACNKR-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  72.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Hydroxamic acid derivatives, the methods for preparation thereof and pharmaceutical compositions comprising thereof, as an active ingredient
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：US20040214896A1

  公开（公告）日：2004-10-28

  Hydroxamic acid derivatives of the formula (I) 1 (wherein all the symbols have the same meaning as defined in the specification.), non-toxic salts thereof or prodrugs thereof. The compounds of the formula (I) inhibit producing IL-6, so it may be used for the prevention and/or treatment of various inflammatory diseases, sepsis, multiple myeloma, plasma cell leukemia, osteoporosis, cachexia, psoriasis, nephritis, renal cell carcinoma, Kaposi's sarcoma, rheumatoid arthritis, hypergammaglobulinemia, Castleman's disease, atrial myxoma, diabetes mellitus, autoimmne diseases, hepatitis, colitis, graft versus host disease, infectious diseases and endometriosis.

  式 (I) 的羟肟酸衍生物 1 (其中所有符号的含义与说明书中的定义相同）、 其无毒盐或原药。 肾细胞癌、卡波西肉瘤、类风湿性关节炎、高丙种球蛋白血症、卡斯特曼病、心房肌瘤、糖尿病、自身免疫性疾病、肝炎、结肠炎、移植物抗宿主疾病、传染病和子宫内膜异位症。
• HYDROXAMIC ACID DERIVATIVES, PROCESS FOR THE PRODUCTION THEREOF AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1215203B1

  公开（公告）日：2005-02-16