N-hydroxy-2-methyl-2-{4-[2-methyl-3''-(2-methylamino-ethoxy)-biphenyl-4-yl]-piperidine-1-sulfonyl}-propionamide | 735255-44-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-hydroxy-2-methyl-2-{4-[2-methyl-3''-(2-methylamino-ethoxy)-biphenyl-4-yl]-piperidine-1-sulfonyl}-propionamide
• 英文别名: N-hydroxy-2-methyl-2-[4-[3-methyl-4-[3-[2-(methylamino)ethoxy]phenyl]phenyl]piperidin-1-yl]sulfonylpropanamide
• CAS: 735255-44-4
• 化学式: C₂₅H₃₅N₃O₅S
• 分子量: 489.636
• InChiKey: SBUWCTGSDDXCCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  116
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-Methyl-2-[4-[3-methyl-4-[3-[2-(methylamino)ethoxy]phenyl]phenyl]piperidin-1-yl]sulfonylpropanoic acid 在 盐酸羟胺 、 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 生成 N-hydroxy-2-methyl-2-{4-[2-methyl-3''-(2-methylamino-ethoxy)-biphenyl-4-yl]-piperidine-1-sulfonyl}-propionamide
  参考文献：
  名称：

  A novel series of highly selective inhibitors of MMP-3

  摘要：

  The design and synthesis of a series of highly selective hydroxamate inhibitors of stromelysin-1 (MMP-3) is described. Substitution of a 4-biaryl piperidine sulfonamide core, which binds at the S1' subsite of MMP-3, was optimised to give potent inhibitors of MMP-3, with greater than 300-fold selectivity over MMP-1, MMP-2, MMP-9 and MMP-14. Compounds 26 and 27 were identified as having the best balance of pharmacology and properties required for topical drug delivery. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.042

文献信息

• METALLOPROTEASE INHIBITORS
  申请人：Pfizer Limited

  公开号：EP1181017B1

  公开（公告）日：2003-04-16