3-[2-[2-benzyl-4-(11,12-dihydro-6H-benzimidazolo[2,1-b][3]benzazepin-6-yl)piperidin-1-yl]ethyl]-2,10-dimethylpyrimido[1,2-a]benzimidazol-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-[2-[2-benzyl-4-(11,12-dihydro-6H-benzimidazolo[2,1-b][3]benzazepin-6-yl)piperidin-1-yl]ethyl]-2,10-dimethylpyrimido[1,2-a]benzimidazol-4-one
• 化学式: C₄₂H₄₂N₆O
• 分子量: 646.8
• InChiKey: ALRXRVBSCPSBNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  49
• 可旋转键数：
  6
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  57
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• NOVEL SUBSTITUTED TETRACYCLIC IMIDAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE AS A MEDICINE
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1401838A2

  公开（公告）日：2004-03-31
• THE USE OF ANTI-HISTAMINICS FOR ACUTE REDUCTION OF ELEVATED INTRACRANIAL PRESSURE
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1451196A1

  公开（公告）日：2004-09-01
• The use of substituted tetracyclic imidazole derivatives as anti-histaminics
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1451196B1

  公开（公告）日：2007-08-15
• JP2009102417A
  申请人：——

  公开号：JP2009102417A

  公开（公告）日：2009-05-14
• Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharamaceutical compositions comprising them and their use as a medicine
  申请人：——

  公开号：US20040167138A1

  公开（公告）日：2004-08-26

  The invention concerns novel substituted tetracyclic imidazole derivatives useful for the treatment of elevated intracranial pressure (ICP) and/or secondary ischaemia, in particular caused by brain injury, more in particular caused by traumatic (TBI) and non-traumatic brain injury, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine. The novel compounds comprise compounds according to the general Formula (I), the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof and the N-oxide form thereof. In particular, the preferred compound is 3-[2-[4-(11,12-dihydro-6H-benzimidazo[2,1-b][3]benzazepin-6-yl)-2-(phenylmethyl)-1-piperidinyl]ethyl]-2,10-dimethyl pyrimido[1,2-a]benzimidazol-4(10H)-one, the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof and the N-oxide form thereof. 1