N-[[(5S)-3-[3-fluoro-4-[(1R,5S)-6-(methylamino)-3-azabicyclo[3.1.0]hexan-3-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-[[(5S)-3-[3-fluoro-4-[(1R,5S)-6-(methylamino)-3-azabicyclo[3.1.0]hexan-3-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
• 化学式: C₁₈H₂₃FN₄O₃
• 分子量: 362.4
• InChiKey: GSXGETDAFOVQIX-NRMMMPIQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  73.9
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Cyclic peroxides as prodrugs for selective delivery of agents
  申请人：The Regents of the University of California

  公开号：US10287312B2

  公开（公告）日：2019-05-14

  Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5]decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.

  本文特别公开了原药组合物以及使用原药组合物治疗和检测疾病的方法。具体地说，本文公开了一种具有螺融合 1，2，4-三氧环和哌啶环的式 (I) 化合物，即 1，2，4-三氧杂-8-氮杂螺[4.5]癸烷。还公开了一种药物组合物，其中含有该化合物和一种药学上可接受的载体。
• CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20220017559A1

  公开（公告）日：2022-01-20

  Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.