[2-methoxy-5-(4-fluorophenyl)benzyl][(2S,3S)-2-phenylpiperidin-3-yl]amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [2-methoxy-5-(4-fluorophenyl)benzyl][(2S,3S)-2-phenylpiperidin-3-yl]amine
• 英文别名: (2S,3S)-N-[[5-(4-fluorophenyl)-2-methoxyphenyl]methyl]-2-phenylpiperidin-3-amine
• 化学式: C₂₅H₂₇FN₂O
• 分子量: 390.501
• InChiKey: WSIZYTAHXOVFPZ-ZCYQVOJMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  33.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 5-Phenylbenzylamine compounds, process for their production and intermediates for their synthesis
  申请人：——

  公开号：US20040097548A1

  公开（公告）日：2004-05-20

  The present invention relates to a 5-phenylbenzylamine compound represented by the formula [1]: 1 wherein Ring A represents a phenyl group having a substituent(s), R a , R b1 and R b2 each represent hydrogen atom, a halogen atom, a lower alkyl group, a halogeno-lower alkyl group or a lower alkoxy group, R c1 represents hydrogen atom, a lower alkyl group optionally substituted by a heterocyclic group, or an acyl group, R c2 and R e each represent hydrogen atom or a lower alkyl group, R d represents hydrogen atom, a lower alkyl group or an acyl group, and R f represents a lower alkyl group or a cyclic lower alkyl group, or a pharmaceutically acceptable salt thereof, a process for preparing the same and synthetic intermediate thereof.

  本发明涉及一种由公式（1）表示的5-苯基苄胺化合物：其中环A代表具有取代基（Ra，Rb1和Rb2）的苯基；Ra，Rb1和Rb2各代表氢原子、卤素原子、较低的烷基、卤代较低的烷基或较低的烷氧基；Rc1代表氢原子、可选地被杂环基取代的较低烷基或酰基；Rc2和Re各代表氢原子或较低的烷基；Rd代表氢原子、较低的烷基或酰基；Rf代表较低的烷基或环状较低的烷基，或其药学上可接受的盐，以及其制备方法和合成中间体。
• 5-PHENYLBENZYLAMINE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND INTERMEDIATES FOR THEIR SYNTHESIS
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1323713A1

  公开（公告）日：2003-07-02

  The present invention relates to a 5-phenylbenzylamine compound represented by the formula [1]: wherein Ring A represents a phenyl group having a substituent(s),    Ra, Rb1 and Rb2 each represent hydrogen atom, a halogen atom, a lower alkyl group, a halogeno-lower alkyl group or a lower alkoxy group,    Rc1 represents hydrogen atom, a lower alkyl group optionally substituted by a heterocyclic group, or an acyl group,    Rc2 and Re each represent hydrogen atom or a lower alkyl group,    Rd represents hydrogen atom, a lower alkyl group or an acyl group, and    Rf represents a lower alkyl group or a cyclic lower alkyl group, or a pharmaceutically acceptable salt thereof, a process for preparing the same and synthetic intermediate thereof.

  本发明涉及一种由式[1]表示的 5-苯基苄胺化合物： 其中环 A 代表具有取代基的苯基、 Ra、Rb1 和 Rb2 各自代表氢原子、卤素原子、低级烷基、卤素-低级烷基或低级烷氧基、 Rc1 代表氢原子、任选被杂环基取代的低级烷基或酰基、 Rc2 和 Re 分别代表氢原子或低级烷基、 Rd 代表氢原子、低级烷基或酰基，以及 Rf 代表低级烷基或环状低级烷基、 或其药学上可接受的盐、制备方法及其合成中间体。
• TREATMENT OF CORNEAL NEOVASCULARIZATION
  申请人：IRBM SCIENCE PARK S.p.A.

  公开号：US20180021327A1

  公开（公告）日：2018-01-25

  There is provided inter alia a compound which is an NK-1 receptor antagonist for use in the treatment or prevention of CNV. There is also provided a compound which is an NK-1 antagonist for use in the treatment of chemical burns of the eye particularly alkali burns of the eye. There is also provided a pharmaceutical composition for topical administration to the eye comprising an NK-1 antagonist and an antibiotic agent.
• NK-1 ANTAGONISTS FOR USE IN THE TREATMENT OF OCULAR PAIN
  申请人：OSPEDALE SAN RAFFAELE S.R.L.

  公开号：US20210015834A1

  公开（公告）日：2021-01-21

  The invention relates to compounds, in particular NK-1 antagonists, for use in the treatment of ocular sensitivity and/or ocular pain.
• US7067535B2
  申请人：——

  公开号：US7067535B2

  公开（公告）日：2006-06-27