4-Amino-8-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-methyl-8H-pteridin-7-one | 195442-60-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 4-Amino-8-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-methyl-8H-pteridin-7-one
• 英文别名: 4-amino-8-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-6-methylpteridin-7-one
• CAS: 195442-60-5
• 化学式: C₃₃H₃₃N₅O₆
• 分子量: 595.655
• InChiKey: IZCLEQUGUULOPW-UPRLRBBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  142
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  丁二酸酐 、 4-Amino-8-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-methyl-8H-pteridin-7-one 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 Succinic acid mono-{(2R,3S,5R)-5-(4-amino-6-methyl-7-oxo-7H-pteridin-8-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester
  参考文献：
  名称：

  Pteridine Nucleosides Analogs of 2′-Deoxyadenosine as Building Blocks for Oligonucleotide Synthesis

  摘要：

  The synthesis, configuration and conformation of adenosine analogous pteridine nucleosides and their conversion into the monomeric building blocks for the automated application in an DNA synthesizer is described.

  DOI：

  10.1080/07328319708002964
• 作为产物：
  描述：

  [(2R,3S,5R)-5-(4-amino-6-methyl-7-oxopteridin-8-yl)-3-(4-chlorobenzoyl)oxyoxolan-2-yl]methyl 4-chlorobenzoate 在 吡啶 、 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 4-Amino-8-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-methyl-8H-pteridin-7-one
  参考文献：
  名称：

  Pteridine Nucleosides Analogs of 2′-Deoxyadenosine as Building Blocks for Oligonucleotide Synthesis

  摘要：

  The synthesis, configuration and conformation of adenosine analogous pteridine nucleosides and their conversion into the monomeric building blocks for the automated application in an DNA synthesizer is described.

  DOI：

  10.1080/07328319708002964

文献信息

• US6716971B1
  申请人：——

  公开号：US6716971B1

  公开（公告）日：2004-04-06
• Pteridine Nucleosides Analogs of 2′-Deoxyadenosine as Building Blocks for Oligonucleotide Synthesis
  作者：Oliver Jungmann、Wolfgang Pfleiderer

  DOI：10.1080/07328319708002964

  日期：1997.5

  The synthesis, configuration and conformation of adenosine analogous pteridine nucleosides and their conversion into the monomeric building blocks for the automated application in an DNA synthesizer is described.