3-amino-4-(4-benzylpiperidin-1-yl)thieno[2,3-b]pyridine-2-carboxylic acid amide | 868062-54-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-amino-4-(4-benzylpiperidin-1-yl)thieno[2,3-b]pyridine-2-carboxylic acid amide
• 英文别名: 3-amino-4-(4-benzylpiperidin-1-yl)thieno[2,3-b]pyridine-2-carboxamide
• CAS: 868062-54-8
• 化学式: C₂₀H₂₂N₄OS
• 分子量: 366.487
• InChiKey: RHIQFMQQVAGWOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• THIENOPYRIDINE DERIVATIVES
  申请人：Sankyo Company, Limited

  公开号：EP1764367A1

  公开（公告）日：2007-03-21

  The present invention provides a compound promoting osteogenesis. The present invention provides a compound having the following general formula (I) wherein R1 is H or alkyl, R2 is RaS-, RaO-, RaNH-, Ra(Rb)N- or cyclic amino, and Ra and Rb are alkyl which may be substituted, cycloalkyl which may be substituted, or the like, or a pharmacologically acceptable salt thereof.

  本发明提供一种促进成骨的化合物。本发明提供具有以下一般式（I）的化合物 其中R1为H或烷基， R2为RaS-、RaO-、RaNH-、Ra(Rb)N-或环状氨基，且 Ra和Rb为可以被取代的烷基、可以被取代的环烷基等，或其药理学上可接受的盐。
• Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
  申请人：Cywin L. Charles

  公开号：US20050288285A1

  公开（公告）日：2005-12-29

  Disclosed are compounds of formula (I): wherein R 1 and R 2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  本发明涉及化合物(I)的公开，其中R1和R2在此定义，这些化合物可用作IκB激酶（IKK）复合物的激酶活性抑制剂。因此，这些化合物可用于治疗由IKK介导的疾病，包括自身免疫性疾病、炎症性疾病和癌症。还公开了包含这些化合物的药物组合物和制备这些化合物的过程。
• Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US20040053957A1

  公开（公告）日：2004-03-18

  Disclosed are compounds of formula (I): 1 wherein R 1 and R 2 are defined herein, which are useful as inhibitors of the kinase activity of the I&kgr;B kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  本发明公开了式(I)的化合物：其中R1和R2在此定义，这些化合物可用作IκB激酶（IKK）复合物的激酶活性抑制剂。因此，这些化合物可用于治疗IKK介导的疾病，包括自身免疫性疾病、炎症性疾病和癌症。本发明还公开了包含这些化合物的制药组合物和制备这些化合物的过程。
• Thienopyridine Derivatives
  申请人：Oizumi Kiyoshi

  公开号：US20070219234A1

  公开（公告）日：2007-09-20

  [Problem to be Solved]The present invention provides a compound promoting osteogenesis. [Solution] The present invention provides a compound having the following general formula (I) wherein R 1 is H or alkyl, R 2 is R a S—, R a O—, R a NH—, R a (R b )N— or cyclic amino, and R a and R b are alkyl which may be substituted, cycloalkyl which may be substituted, or the like, or a pharmacologically acceptable salt thereof.

  【待解决的问题】本发明提供了一种促进成骨作用的化合物。 【解决方案】本发明提供了一种具有以下通式（I）的化合物，其中R1为H或烷基，R2为RaS—、RaO—、RaNH—、Ra（Rb）N—或环状氨基，而Ra和Rb为可被取代的烷基、可被取代的环烷基等，或其药理学上可接受的盐。
• 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amides
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：EP2008654A1

  公开（公告）日：2008-12-31

  Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  所公开的是式 (I) 化合物： 其中 R1 和 R2 在此定义，可用作 IκB 激酶（IKK）复合物激酶活性的抑制剂。因此，这些化合物可用于治疗 IKK 介导的疾病，包括自身免疫性疾病、炎症性疾病和癌症。此外，还公开了包含这些化合物的药物组合物以及制备这些化合物的工艺。